||Spermotoxicity and Tissue Accumulation of Chlordecone (Kepone) in Male Rats.
Linder, R. ;
Scotti, T. M. ;
McElroy, W. K. ;
Laskey, J. W. ;
Strader, L. F. ;
||Health Effects Research Lab., Research Triangle Park, NC. ;Northrup Services, Inc., Research Triangle Park, NC.
Chlorine organic compounds ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||Adult male rats were fed diets containing 0, 5, 15, and 30 ppm chlordecone for 90 d and then either bred to untreated females or sacrificed for terminal studies. Chlordecone residues in liver, fat, and serum were determined in the treated males. Reproductive performance was unaffected, and no histologic changes in the male sex organs could be attributed to chlordecone treatment. Reversible decreases in the motility and viability of epididymal spermatozoa and decreased sperm reserves in the cauda epididymidis were observed in rats fed 15 or 30 ppm. No effect on sperm morphology or on sperm concentration in epididymal fluid was detected. Chlordecone accumulation in tissues was linearly related to dietary levels, with the highest chlordecone concentration occurring in the liver.
||Prepared in cooperation with Northrop Services, Inc., Research Triangle Park, NC.
||Pub. in Jnl. of Toxicology and Environmental Health 12, p183-192, 1983.
|NTIS Title Notes
||Reprint: Spermotoxicity and Tissue Accumlation of Chlordecone (Kepone) in Male Rats.
|PUB Date Free Form
||6T; 57Y; 68E
||Not available NTIS