| Main Title |
Short term toxicity (1 and 10 day gavage) of barium chloride in male and female rats / |
| Author |
Borzelleca, Joseph F. ;
Condie, L. W. ;
Egle, J. L.
|
| Other Authors |
|
| CORP Author |
Health Effects Research Lab., Cincinnati, OH. Toxicology and Microbiology Div. ;Virginia Commonwealth Univ., Richmond. Dept. of Pharmacology and Toxicology. |
| Publisher |
U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory, |
| Year Published |
1988 |
| Report Number |
EPA/600/J-88/318 |
| Stock Number |
PB89-207310 |
| Additional Subjects |
Toxicity ;
Potable water ;
Rats ;
In vitro analysis ;
Lethal doses ;
Laboratory animals ;
Exposure ;
Tables(Data) ;
Reprints ;
Barium chlorides ;
Water quality ;
Dose-response relationships ;
Water pollution effects
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB89-207310 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
14 pages ; 28 cm |
| Abstract |
To assess adverse effects that might be caused by an event resulting in high levels of barium in drinking water, rats were gavaged with barium chloride (BaCl2 at dosage levels of 30, 100, and 300 mg/kg in a 1-day study and at 100, 145, 209, and 300 mg/kg for 10 days) and the effects were determined. LD50 values for male and female rates were found to be 419 (352-499) and 408 (342-487) mg/kg BaCl2, respectively. In the 1-day exposure study, decreases in body weight and liver/brain weight ratios and increase in kidney weight as a percentage of body weight appeared to be related to barium ingestion at 300 mg/kg. After 10 days of exposure to barium, survival of females was substantially lower at 300 mg/kg. A reduction in ovaries/brain ratio at 300 mg/kg appeared to be barium-induced. There was a decrease in BUN at 300 mg/kg in males and at all dose levels in females. No other effects were attributed to barium. Histopathological findings were negative in both the 1- and 10-day studies. It is concluded the short-term oral exposure to BaCl2 at doses up to 209 mg/kg produces no significant adverse health effects. |
| Notes |
Includes bibliographical references. "Reprint article published in Journal of the American College of Toxicology, vol. 7, no. 5, pp. 675-685, 1988." "Lyman Condie, project officer." "Contract no. CR812558." Microfiche. |
| Place Published |
Research Triangle Park, N.C. : |
| Supplementary Notes |
Pub. in Jnl. of the American College of Toxicology, v7 n5 p675-685 Dec 88. Prepared in cooperation with Virginia Commonwealth Univ., Richmond. Dept. of Pharmacology and Toxicology. |
| Corporate Au Added Ent |
United States. Environmental Protection Agency. Office of Research and Development. ; Health Effects Research Laboratory. Toxicology and Microbiology Division. ; Medical College of Virginia. Department of Pharmacology and Toxicology. |
| Alternate Title |
Short term toxicity of barium chloride in male and female rats. |
| PUB Date Free Form |
1988. |
| NTIS Prices |
PC A03/MF A01 |
| BIB Level |
m |
| Cataloging Source |
OCLC/T |
| OCLC Time Stamp |
20000815125425 |
| Language |
eng |
| Origin |
NTIS |
| Type |
MERGE |
| OCLC Rec Leader |
01591nam 2200325Ka 45020 |
