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Main Title Triggering of a Cytolytic Factor with TNF-Like Activity from Human Monocytes.
Author Koren, H. S. ; McKinnon, K. P. ; Chen, A. R. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Clinical Research Branch. ;Duke Univ. Medical Center, Durham, NC.
Year Published 1986
Report Number EPA/600/D-86/127;
Stock Number PB87-129565
Additional Subjects Monocytes ; Humans ; Protein ; Toxicity ; In vivo analysis ; Cytolytic factor ; TNF ; Cytolytic monokine
Library Call Number Additional Info Location Last
NTIS  PB87-129565 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 36p
Abstract Monocytes have a nonoxidative mechanism of tumor cytolysis operative in CGD and in normal monocytes under anaerobic conditions. The absence of competitive inhibition provides negative evidence for a contact-independent mechanism of cytolysis, confirmed by the demonstration of a soluble mediator secreted independently of effector-target cell contact. This cytolytic monokine, a protein of apparent molecular weight between 25,000 and 40,000, resembles TNF functionally and antigenically. Further work will be required to demonstrate its biochemical identity, its precise mechanism of toxicity, and the extent of its importance in vivo.
Supplementary Notes Prepared in cooperation with Duke Univ. Medical Center, Durham, NC.
PUB Date Free Form Jul 86
Category Codes 57F; 57B
NTIS Prices PC A03/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 706516722
Origin NTIS
Type CAT