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Main Title Inhibition of Human Natural Killer Cell Activity Following In vitro Exposure to Ozone.
Author Harder, S. D. ; Harris, D. T. ; Hose, D. ; Koren., H. S. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Clinical Research Branch.;North Carolina Univ. at Chapel Hill.
Publisher c1990
Year Published 1990
Report Number EPA/600/J-90/079;
Stock Number PB90-245473
Additional Subjects Toxicology ; Ozone ; Humans ; In vitro analysis ; Exposure ; Reprints ; Natural killer cells ; Cultured tumor cells ; Cell survival ; Binding sites
Library Call Number Additional Info Location Last
NTIS  PB90-245473 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 15p
Abstract In the study the effect of in vitro ozone exposure on human peripheral blood natural killer (NK) cell activity measured against K562 tumor cells has been examined. The data showed that NK activity was inhibited in a time dependent manner with marked suppression observed after 6 hours of ozone exposure. Significant inhibition occurred at three different levels of ozone exposure (1.0, 0.5 and 0.18 ppm) and E/T ratios of (50:1, 25:1 and 12.5:1). The ozone effect was not merely a nonspecific toxicity as NK activity recovered within 18 hours following exposure either spontaneously or by stimulation with IL 2. Moreover, unexposed cells treated with supernatant from ozone exposed cells showed no decrease in NK activity. A direct effect of ozone on the natural killer cells was suggested by the finding of suppressed activity in an NK enriched population. Since conjugate formation of the ozone exposed NK cells with K562 targets was unchanged the authors assume that the inhibitory effect of ozone was at a post binding step in the lytic pathway. (Copyright (c) 1990 by Hemisphere Publishing Corporation.)
Supplementary Notes Pub. in Inhalation Toxicology, v2 n2 p161-173 Apr 90. Sponsored by North Carolina Univ. at Chapel Hill.
NTIS Title Notes Journal article.
Title Annotations Reprint: Inhibition of Human Natural Killer Cell Activity Following In vitro Exposure to Ozone.
Category Codes 57Y; 57F
NTIS Prices PC A03/MF A01
Primary Description 600/10
Document Type NT
Cataloging Source NTIS/MT
Control Number 024228033
Origin NTIS
Type CAT