||Mirex Induces Ornithine Decarboxylase in Female Rat Liver.
Mitra, A. ;
Richards, I. ;
Kitchin, K. ;
Conolly, R. ;
Kulkarni, A. P. ;
||University of South Florida, Tampa. Coll. of Public Health. ;Chemical Industry Inst. of Toxicology, Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC.
Ornithine decarboxylase ;
Enzyme induction ;
Dose-response relationships ;
Statistical analysis ;
||Some EPA libraries have a fiche copy filed under the call number shown.
||Ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine synthesis, was significantly induced in female rat liver following oral administration of the pesticide, mirex. After dual oral exposure (120 mg/kg; 21 and 4 hrs. prior to sacrifice) induction of ODC activity in rat liver cytosol was 70-fold as compared to controls. A single oral dose of mirex (180 mg/kg) induced hepatic ODC activity 55-fold over controls. The time-course study indicated that maximal induction of ODC activity after a single oral dose of mirex was at 36 hours post-dosing. Though the exact mechanisms is still unclear, it appears that sex could be a pre-disposing factor in the induction of ODC activity in rat liver. Mirex is an unusually strong and long lasting inducer of rat hepatic ODC activity. (Copyright (c) 1990 VCH Publishers, Inc.)
||Pub. in Jnl. of Biochemical Toxicology, v5 n2 p119-124 Jul 90. Prepared in cooperation with Chemical Industry Inst. of Toxicology, Research Triangle Park, NC. Sponsored by Health Effects Research Lab., Research Triangle Park, NC.
|NTIS Title Notes
||Reprint: Mirex Induces Ornithine Decarboxylase in Female Rat Liver.
||57Y; 57F; 68E
||PC A02/MF A01