| Main Title |
Metabolism of 1-Nitropyrene by Cultured Rabbit Alveolar Macrophages and Respiratory Tract Tissues. |
| Author |
King, L. C. ;
Ball, L. M. ;
Jackson, M. ;
Inmon, J. P. ;
Lewtas, J. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC. |
| Year Published |
1986 |
| Report Number |
EPA/600/J-86/032; |
| Stock Number |
PB86-190121 |
| Additional Subjects |
Toxicology ;
Metabolism ;
Macrophages ;
Tissues(Biology) ;
Reprints ;
Nitropyrene ;
Metabolites
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB86-190121 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
11p |
| Abstract |
The metabolism of 1-nitropyrene (1-NP) was studied in cultured rabbit alveolar macrophages and respiratory tissues from both lung and trachea. Metabolites from the incubation medium and from the macrophages and respiratory tissues were isolated and quantitated by HPLC. The following metabolites were isolated and quantitated: 1-nitro-pyrene-4,5- or -9,10-dihydrodiol (K-DHD), N-acetyl-1-aminopyrene (NAAP), 1-aminopyrene (1-AMP), 10-hydroxy-1-nitropyrene (10-OH-1-NP), 4-,5-,6-,8- or 9-monohydroxy-1-nitropyrene (phenols), and 3-hydroxy-1-nitropyrene (3-OH-1-NP). The total percentage of 1-NP metabolism was significantly greater in the lung and tracheal tissue (28.0 to 23.0% of the recovered 14C, respectively) compared to the alveolar macrophages (6.3%). The tracheal tissue was found to have the highest activity both in 1-NP metabolism and intracellular metabolite concentration. A major portion of the 1-NP metabolites produced were released into the incubation medium. |
| Supplementary Notes |
Pub. in Toxicology and Applied Pharmacology 82, n2 p292-300 Feb 86. Prepared in cooperation with Northrop Services, Inc., Research Triangle Park, NC. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Metabolism of 1-Nitropyrene by Cultured Rabbit Alveolar Macrophages and Respiratory Tract Tissues. |
| PUB Date Free Form |
c1986 |
| Category Codes |
6T; 6O; 57Y; 57Q |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
617121924 |
| Origin |
NTIS |
| Type |
CAT |
