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OLS Field Name OLS Field Data
Main Title Embryonic Development in vitro Following Short-Duration Exposure to Heat.
Author Kimmel, G. L. ; Cuff, J. M. ; Kimmel, C. A. ; Heredia, D. J. ; Tudor, N. ;
CORP Author Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment. ;Thiel Coll., Greenville, PA. Dept. of Biology. ;Food and Drug Administration, Rockville, MD. Center for Devices and Radiological Health.
Publisher c1993
Year Published 1993
Report Number EPA/600/J-93/186 ;OHEA-R-496;
Stock Number PB93-194538
Additional Subjects Embryo development ; Induced hyperthermia ; Heat ; Rats ; Body temperature ; In vitro analysis ; Growth ; Animal pregnancy ; Exposure ; Reprints ;
Holdings
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NTIS  PB93-194538 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 08/23/1993
Collation 11p
Abstract Gestation day (GD) 10 rat embryos (10-12 somites) were exposed in vitro for 10 to 25 mins at 42 C or 43 C and evaluated 24 hrs later for alterations in growth and specific morphological parameters, using a modified Brown-Fabro scoring system that allowed evaluation of development relative to gestational age. At 42 C, crown-rump length appeared to be particularly sensitive, responding to only 10 mins exposure. A 15-min exposure resulted in decreased total protein, somite number and morphological score. At 43 C, all of the parameters measured were affected by a 10-min exposure. The response patterns demonstrated a clear temperature- and exposure duration-dependency, with a shift from a more shallow duration-response curve to a more dramatic inhibition of development as temperature increased from 42 C to 43 C.
Supplementary Notes Pub. in Teratology 47, p243-251 Feb 93. Prepared in cooperation with Thiel Coll., Greenville, PA. Dept. of Biology, and Food and Drug Administration, Rockville, MD. Center for Devices and Radiological Health.
NTIS Title Notes Journal article.
Title Annotations Reprint: Embryonic Development in vitro Following Short-Duration Exposure to Heat.
Category Codes 57W; 57S
NTIS Prices PC A03/MF A01
Primary Description 600/21
Document Type NT
Cataloging Source NTIS/MT
Control Number 318932036
Origin NTIS
Type CAT