| Main Title |
Embryonic Development in vitro Following Short-Duration Exposure to Heat. |
| Author |
Kimmel, G. L. ;
Cuff, J. M. ;
Kimmel, C. A. ;
Heredia, D. J. ;
Tudor, N. ;
|
| CORP Author |
Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment. ;Thiel Coll., Greenville, PA. Dept. of Biology. ;Food and Drug Administration, Rockville, MD. Center for Devices and Radiological Health. |
| Publisher |
c1993 |
| Year Published |
1993 |
| Report Number |
EPA/600/J-93/186 ;OHEA-R-496; |
| Stock Number |
PB93-194538 |
| Additional Subjects |
Embryo development ;
Induced hyperthermia ;
Heat ;
Rats ;
Body temperature ;
In vitro analysis ;
Growth ;
Animal pregnancy ;
Exposure ;
Reprints ;
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB93-194538 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
11p |
| Abstract |
Gestation day (GD) 10 rat embryos (10-12 somites) were exposed in vitro for 10 to 25 mins at 42 C or 43 C and evaluated 24 hrs later for alterations in growth and specific morphological parameters, using a modified Brown-Fabro scoring system that allowed evaluation of development relative to gestational age. At 42 C, crown-rump length appeared to be particularly sensitive, responding to only 10 mins exposure. A 15-min exposure resulted in decreased total protein, somite number and morphological score. At 43 C, all of the parameters measured were affected by a 10-min exposure. The response patterns demonstrated a clear temperature- and exposure duration-dependency, with a shift from a more shallow duration-response curve to a more dramatic inhibition of development as temperature increased from 42 C to 43 C. |
| Supplementary Notes |
Pub. in Teratology 47, p243-251 Feb 93. Prepared in cooperation with Thiel Coll., Greenville, PA. Dept. of Biology, and Food and Drug Administration, Rockville, MD. Center for Devices and Radiological Health. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Embryonic Development in vitro Following Short-Duration Exposure to Heat. |
| Category Codes |
57W; 57S |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/21 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
318932036 |
| Origin |
NTIS |
| Type |
CAT |
