| Main Title |
Relationship between Abnormal Somite Development and Axial Skeletal Defects in Rats Following Heat Exposure. |
| Author |
Cuff, J. M. ;
Kimmel, G. L. ;
Kimmel, C. A. ;
Heredia, D. J. ;
Tudor, N. ;
|
| CORP Author |
Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment. ;Thiel Coll., Greenville, PA. Dept. of Biology. ;Food and Drug Administration, Rockville, MD. Center for Devices and Radiological Health. |
| Publisher |
c1993 |
| Year Published |
1993 |
| Report Number |
EPA/600/J-93/508 ;OHEA-R-498; |
| Stock Number |
PB94-135159 |
| Additional Subjects |
Heat ;
Skeleton ;
Congenital abnormalities ;
Rats ;
Prenatal exposure delayed effects ;
In vivo analysis ;
In vitro analysis ;
Reprints ;
Somites
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB94-135159 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
8p |
| Abstract |
The effects of in vivo heat exposure on gestation day (GD) 10 rat embryos were evaluated on GD 11 to determine the relationships between morphological sequelae following in vivo and in vitro exposures and between effects detected on GD 11 and those observed in postnatal day (PND) 3 pups. Anesthetized rats were exposed to 42 C in a warm air incubator until their rectal temperatures reached 41 C or until a rectal temperature of 42-42.5 C had been maintained for 5 minutes. Heat-exposed embryos exhibited a significant decrease in growth parameters including head length, somite number, and protein content/embryo versus controls. Among the morphological endpoints which were slightly delayed in development were the caudal neural tube, branchial bars, forelimb and hindlimb. The only effect on the embryos that could not be explained as a transient delay in development induced by heat was the induction of unsegmented somites. Additional embryos were exposed to 42 C for 15-20 min in vitro and examined specifically for unsegmented somites, which were observed in 47% of embryos exposed to 42 C in vivo or in vitro. |
| Supplementary Notes |
Pub. in Teratology 48, p259-266 1993. Prepared in cooperation with Thiel Coll., Greenville, PA. Dept. of Biology, and Food and Drug Administration, Rockville, MD. Center for Devices and Radiological Health. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Relationship between Abnormal Somite Development and Axial Skeletal Defects in Rats Following Heat Exposure. |
| Category Codes |
57W; 57S |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/21 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
407718956 |
| Origin |
NTIS |
| Type |
CAT |
