Full Record Display for the EPA National Library Catalog

RECORD NUMBER: 6 OF 74

OLS Field Name OLS Field Data
Main Title Application of benchmark dose methodology to data from prenatal developmental toxicity studies.
Author Kimmel, C. A. ; Kavlock, R. J. ; Allen, B. C. ; Faustman, E. M.
Other Authors
Author Title of a Work
Kimmel, C. A.
Kavlock, R. J.
Allen, B. C.
Faustman, E. M.
CORP Author Environmental Protection Agency, Washington, DC. National Center for Environmental Assessment. ;Washington Univ., Seattle. Dept. of Environmental Health. ;ICF Kaiser, Research Triangle Park, NC.
Publisher National Risk Management Research Laboratory,
Year Published 1995
Report Number NCEA-W-017; EPA/600/A-95/135
Stock Number PB96-117536
Additional Subjects Toxicity ; Risk assessment ; Dose-response relationships ; Fetal development ; Dosage ; Weight measurement ; Experimental data ; Models ; Statistical analysis ; Benchmark dose
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB96-117536 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 01/01/1988
Collation 17 pages
Abstract The benchmark dose (BMD) concept was applied to 246 conventional developmental toxicity datasets from government, industry and commercial laboratories. Five modeling approaches were used, two generic and three specific to developmental toxicity (DT models). BMDs for both quantal and continuous data were compared with statistically-derived NOAELs (NOSTASOTs) to determine similarities. Quantal (Q) endpoints included litter responses (e.g., one or more dead or malformed implants), and QBMDs were calculated using a quantal Weibull (QW) model. Two types of continuous (C) data were modeled, the proportion of implants affected per litter, and the change in fetal weight (both mean and distribution); continuous power (CP) and DT models were used to calculate CBMDs. The results support the use of BMDs as providing a more consistent basis for risk assessment than do NOAELs.
Notes "July 1995." "NCEA-W-017." "PB96-117536."
Place Published Cincinnati, OH :
Supplementary Notes Prepared in cooperation with Washington Univ., Seattle. Dept. of Environmental Health. and ICF Kaiser, Research Triangle Park, NC.
Corporate Au Added Ent United States. Environmental Protection Agency, National Center for Environmental Assessment. ; Washington University, Department of Environmental Health (Seattle, Washington). ; ICF Kaiser (Research Triangle Park, NC).
PUB Date Free Form {1995}.
NTIS Prices PC A03/MF A01
BIB Level m
Cataloging Source OCLC/T
OCLC Time Stamp 20030414172313
Language eng
Origin NTIS
Type MERGE
OCLC Rec Leader 01075nam 2200301Ka 45020