||Effects of Neonatal Methylmercury Exposure on Adrenergic Receptor Binding Sites in Peripheral Tissues of the Developing Rat.
Slotkin, T. A. ;
Kavlock, R. J. ;
Cowdery, T. ;
Orband, L. ;
Bartolome, M. ;
||Duke Univ. Medical Center, Durham, NC. Dept. of Pharmacology.;Health Effects Research Lab., Research Triangle Park, NC.
Laboratory animals ;
Adrenergic receptor binding sites
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||Neonatal exposure to methylmercury produces changes in patterns of tissue growth and function, in part, due to alterations in adrenergic neuronal input. To explore the mechanisms by which these changes come about, newborn rats were exposed to methylmercury (1 or 2.5 mg/kg/day) throughout the preweaning stage and the ontogeny of adrenergic receptor binding sites evaluated in liver, kidney, heart and lung, using (3H)prazosin (alpha 1-receptors), (3H)rauwolscine (alpha 2-receptors) and (125I)pindolol (beta-receptors). In the kidney, methylmercury caused decreases in beta- and alpha 1-receptor binding and increases in alpha 2-binding, and the alterations persisted into adulthood; previous work has shown that beta-receptor-mediated responses are generally enhanced in methylmercury-exposed pups, and the down-regulation of beta-receptor binding thus probably represents a compensatory action secondary to alterations in post-receptor coupling mechanisms. The effects of methylmercury on hepatic adrenergic receptors were different from those seen in the kidney, with substantial elevations in beta- and alpha-receptor binding apparent in the preweaning stage; this agrees also with the differences in effects of the mercurial on trophic reactivity and growth in the two tissues.
||Pub. in Toxicology, v41 p95-106 1986. See also report dated 1985, PB86-120334. Sponsored by Health Effects Research Lab., Research Triangle Park, NC.
|NTIS Title Notes
||Reprint: Effects of Neonatal Methylmercury Exposure on Adrenergic Receptor Binding Sites in Peripheral Tissues of the Developing Rat.
|PUB Date Free Form
||PC A03/MF A01