| Main Title |
Toxicity of Mercuric Chloride to the Developing Rat Kidney. 3. Distribution and Elimination of Mercury during Postnatal Maturation. |
| Author |
Daston, G. P. ;
Rehnberg, B. F. ;
Hall, L. L. ;
Kavlock, R. J. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Wisconsin Univ.-Milwaukee. Dept. of Biological Sciences. |
| Publisher |
c1986 |
| Year Published |
1986 |
| Report Number |
EPA/600/J-86/480; |
| Stock Number |
PB89-105456 |
| Additional Subjects |
Toxicology ;
Mercuric chloride ;
Rats ;
Kidneys ;
Dosage ;
Metabolism ;
Reprints ;
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB89-105456 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
11p |
| Abstract |
Mercuric chloride is a potent nephrotoxin in the adult rat, but has little effect on newborns. Nephrotoxicity increases with postnatal maturation. The study assesses the changes in tissue distribution and excretion of Hg during postnatal development. Sprague Dawley rats were injected so with 5 mg/kg (203)HgCl2 on postnatal day 1, 8, 15, 22 or 29. Hg concentration was measured in the whole body, renal cortex, medulla and papilla, liver, and subcellular fractions of liver and kidney. Binding to cytosolic metallothionein was assessed. |
| Supplementary Notes |
Pub. in Toxicology and Applied Pharmacology 85, p39-48 May 86. See also PB85-124600. Prepared in cooperation with Wisconsin Univ.-Milwaukee. Dept. of Biological Sciences. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Toxicity of Mercuric Chloride to the Developing Rat Kidney. 3. Distribution and Elimination of Mercury during Postnatal Maturation. |
| Category Codes |
57Y |
| NTIS Prices |
Not available NTIS |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
834421673 |
| Origin |
NTIS |
| Type |
CAT |
