| Contents Notes |
Introduction:History and Scope of This Book -- Cholinergic Cells and Pathways -- Metabolism of Acetylcholine: Synthesis and Turnover -- History of Research on Nicotinic and Muscarinic Cholinergic Receptors -- Muscarinic Acetylcholine Receptors in the Central Nervous System: Structure, Function, and Pharmacology -- Neuronal Nicotinic Receptors: History, Structure, and Functional Roles -- Anticholinesterases and War Gases -- Cholinergic Aspects of Growth and Development -- Central Cholinergic Nervous System and Its Correlates -- Links Between Amyloid and Tau Biology in Alzheimer's Disease and Their Cholinergic Aspects -- Envoi. The saga of the central cholinergic nervous system is unparalleled among the stories of various areas of neurosciences. Exploring the Vertebrate Central Cholinergic Nervous System reviews the very multiple methodologies that underlie cholinergic research. The book is historical, dynamic and conceptual in its approach. It stresses the concept and devotes considerable space to the history of the various topics of cholinergic research and modes of cholinergic discoveries. The volume provides the reader with a very complete overview of cholinergicity and its ramifications and will be of interest to investigators, scholars and students of various areas of neuroscience and neuroanatomy. The volume's eleven chapters cover a wide variety of topics including the complexity of synthesis of acetylcholine, cholinesterases, cholinergic teratology, anticholinesterase agents, clinical use of cholinergic drugs, central cholinergic pathways and behaviors with cholinergic correlates. The figures and diagrams help illustrate various subjects and its photographs of "cholinergikes" of the past and present bring a personal note to the book. The book illustrates the peaks that have been reached in the course of the history of cholinergic research and challenges the perennial frontier of human science: the understanding of ourselves. "...This reactivated my synaptic circuitry devoted to science and history....Exploring the Vertebrate Cholinergic Nervous System is a impressive picture of one century of cholinergic adventure..." --Yves Dunant, University of Geneva "I have long believed that the 'cholinergic saga' needs to be told, and no one is better equipped to do that than Alex Karczmar." --Larry Butcher, University of California, Los Angeles |
