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Main Title Allylisopropylacetamide Induces Rat Hepatic Ornithine Decarboxylase (Journal Version).
Author Kitchin, K. T. ; Brown, J. L. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Publisher 1987
Year Published 1987
Report Number EPA/600/J-87/422;
Stock Number PB89-105951
Additional Subjects Allylisopropylacetamide ; Ornithine decarboxylase ; Porphyrinogens ; Enzyme induction ; Liver ; Laboratory animals ; Amides ; Reprints ; Acetamide/allylisopropyl
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NTIS  PB89-105951 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 11p
Abstract Allylisopropylacetamide (AIA) did not cause DNA damage in rat liver. The porphyrinogenic research drug did strongly induce the activity (25-fold) of rat hepatic enzyme ornithine decarboxylase (ODC). By either the oral or the subcutaneous route AIA produced a long lasting induction (30-40 hr) of hepatic ODC activity. Four analogs of AIA, 2-propyl-2-isopropylacetamide (PIA), allobarbital, allylbenzene and allylacetate were examined for their ability to induce hepatic ODC. PIA, allylbenzene and allobarbital were active ODC inducers while allylacetate was not. Although induction of hepatic ALA synthetase activity and the accumulation of hepatic porphyrins depends on the allyl moiety of AIA, this was not the case with hepatic ODC induction. AIA did not elevate serum alanine aminotransferase (SGPT), and thus hepatic cell death is not a likely explanation of AIA's long lasting induction of ODC. As AIA does not belong in any of the common categories of ODC inducers, it is possible that AIA may be the chemical prototype of a new class of hepatic ODC inducers.
Supplementary Notes Pub. in Jnl. of Biochemical Toxicology, v2 p215-223 1987.
NTIS Title Notes Journal article.
Title Annotations Reprint: Allylisopropylacetamide Induces Rat Hepatic Ornithine Decarboxylase (Journal Version).
Category Codes 57Q; 57B
NTIS Prices PC A03/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 834422002
Origin NTIS
Type CAT