Main Title |
Comparison of the D1-Dopamine Agonists SKF-38393 and A-68930 in Neonatal 6-Hydroxydopamine-Lesioned Rats: Behavioral Effects and Industion of c-fos-Like Immunoreactivity. |
Author |
Johnson, K. B. ;
Criwell, H. E. ;
Jensen, K. F. ;
Simson, P. E. ;
Mueller, R. A. ;
|
CORP Author |
North Carolina Univ. at Chapel Hill. School of Medicine.;Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. |
Publisher |
c1992 |
Year Published |
1992 |
Report Number |
EPA/600/J-92/375; |
Stock Number |
PB93-107209 |
Additional Subjects |
Dopamine receptors ;
Proto-oncogene proteins c-fos ;
Pharmacology ;
Oxidopamine ;
Comparison ;
Locomotion ;
Rats ;
Corpus striatum ;
Immunohistochemistry ;
Animal behavior ;
Reprints ;
SKF-38393 ;
A-68930
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB93-107209 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
13p |
Abstract |
Administration of the selective D1-dopamine receptor agonist 2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine (SKF-38393) to neonatal 6-hydroxydopamine-lesioned rats results in profound behavioral manifestations and induction of striatal c-fos-like immunoreactivity. The full D1-dopamine agonist l,(R,S)1-aminomethyl-3,4-dihydro-5,6-dihydroxy-3-phenyl-1H-2-benzopyran hydrochloride (A-68930), like SKF-38393, produced a dose-dependent, D1-selective increase in locomotor activity and striatal c-fos-like immunoreactivity. These results with A-68930 provide additional evidence that the specific behavioral and biochemical responses observed in neonatally lesioned rats after SKF-38393 administration are due to actions on D1-dopamine receptors, and indicate that A-68930 provides a new tool for investigating D1-dopamine receptor function. |
Supplementary Notes |
Pub. in Jnl. of Pharmacology and Experimental Therapeutics, v262 n2 p855-865 Aug 92. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Comparison of the D1-Dopamine Agonists SKF-38393 and A-68930 in Neonatal 6-Hydroxydopamine-Lesioned Rats: Behavioral Effects and Industion of c-fos-Like Immunoreactivity. |
Category Codes |
57Q; 57F |
NTIS Prices |
PC A03/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
234225638 |
Origin |
NTIS |
Type |
CAT |