Main Title |
Model of the Regional Uptake of Gaseous Pollutants in the Lung. 1. The Sensitivity of the Uptake of Ozone in the Human Lung to Lower Respiratory Tract Secretions and Exercise. |
Author |
Miller, F. J. ;
Overton, J. H. ;
Jaskot, R. H. ;
Menzel, D. B. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC. ;Duke Univ. Medical Center, Durham, NC. |
Year Published |
1985 |
Report Number |
EPA/600/J-85/113; |
Stock Number |
PB85-243970 |
Additional Subjects |
Lung ;
Ozone ;
Toxicology ;
Gases ;
Models ;
Sensitivity ;
Respiratory system ;
Exercise(Physiology) ;
Pathology ;
Reprints ;
Air pollution effects(Humans)
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB85-243970 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
18p |
Abstract |
A model of the Regional Uptake of Gaseous Pollutants in the Lung. I. The sensitivity of the Uptake of Ozone in the Human Lung to Lower Respiratory Tract Secretions and to Exercise. Miller, F.J., Overton, J.H., Jr., Jaskot, R.H., and Menzel, D.B. (1984). Toxicol. Appl. Pharmacol. An ozone (O3) dosimetry model is presented that takes into account convection and diffusion of O3 in the lumen and airspaces of the lower respiratory tract and transport and chemical reactions in the mucous and surfactant layers and in the underlying tissue and capillaries. The model was applied to human airway morphometric data. Values for the chemical and physical parameters that define the liquid tissue and blood compartments were based on reported experimental data. Simulation results illustrate the variability of results due to an uncertainty in the knowledge of transport parameters, liquid, tissue, and blood compartment thickness, and chemical reaction rates. |
Supplementary Notes |
Prepared in cooperation with Northrop Services, Inc., Research Triangle Park, NC., and Duke Univ. Medical Center, Durham, NC. |
Availability Notes |
Pub. in Toxicology and Applied Pharmacology 79, n1 p11-27 Jun 85. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Model of the Regional Uptake of Gaseous Pollutants in the Lung. 1. The Sensitivity of the Uptake of Ozone in the Human Lung to Lower Respiratory Tract Secretions and Exercise. |
PUB Date Free Form |
c1985 |
Category Codes |
6E; 6T; 57O; 57Y |
NTIS Prices |
Not available NTIS |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
529826616 |
Origin |
NTIS |
Type |
CAT |