| Main Title |
Kinetics of In vivo Sister Chromatid Exchange Induction in Mouse Bone Marrow Cells in Ethylnitrosourea and Methylnitrosourea. |
| Author |
Charles, J. L. ;
Jacobson-Kram, D. ;
Condie, L. ;
Borzelleca, J. F. ;
Carchman, R. A. ;
|
| CORP Author |
Virginia Commonwealth Univ., Richmond. Dept. of Pharmacology and Toxicology.;Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1986 |
| Report Number |
EPA-R-808861; EPA/600/J-86/158; |
| Stock Number |
PB87-118501 |
| Additional Subjects |
Bone marrow ;
Toxicology ;
Laboratory animals ;
Mice ;
Kinetics ;
Reprints ;
Sister chromatid exchange ;
Urea/ethylnitroso ;
Urea/methylnitroso
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB87-118501 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
12p |
| Abstract |
Administration of ethylnitrosourea (ENU) (20, 25, 40, 50, and 60 mg/kg body weight) or methylnitrosourea (MNU) (25, 40, 50, 60, 75, and 80 mg/kg body weight) to male CD-1 mice 2 hours after subcutaneous implantation of 5-bromo-2'-deoxyurdine (BrdUrd) pellet (55 mg) resulted in a dose-dependent increase in sister chromatid exchanges (SCE) in bone marrow cells. Treatment with ENU (50 mg/kg body weight) at several time points prior to BrdUrd implantation resulted in a biphasic curve of SCE induction indicating at least two events that result in SCEs. Treatment with ENU at the time of BrdUrd implantation and post-BrdUrd reflected a similar mechanism apparent in the preBrdUrd curve. Treatment with MNU (50 mg/kg body weight) pre- and post-BrdUrd resulted in a linear monophasic curve of SCE induction in both the pre- and post-BrdUrd time periods. The overall MNU time-course curve resembled an inverted V function indicating the mechanism of SCE induction for ENU and MNU are different. |
| Supplementary Notes |
See also PB85-150845. Pub. in Toxicology and Applied Pharmacology 84, p56-65 Jun 86. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Kinetics of In vivo Sister Chromatid Exchange Induction in Mouse Bone Marrow Cells in Ethylnitrosourea and Methylnitrosourea. |
| PUB Date Free Form |
c1986 |
| Category Codes |
57Y; 57Q |
| NTIS Prices |
PC A02/MF A01 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
703717619 |
| Origin |
NTIS |
| Type |
CAT |
