| Main Title |
Factors That Influence the Suppression of Pulmonary Antibacterial Defenses in Mice Exposed to Ozone. |
| Author |
Gilmour, M. I. ;
Park, P. ;
Doerfler, D. ;
Selgrade, M. J. K. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;North Carolina Univ. at Chapel Hill. Center for Environmental Medicine and Lung Biology. |
| Publisher |
1993 |
| Year Published |
1993 |
| Report Number |
EPA/600/J-93/398; |
| Stock Number |
PB93-236354 |
| Additional Subjects |
Ozone ;
Anti-infective agents ;
Air pollution effects(Animals) ;
Immunosuppression ;
Mice ;
Phagocytosis ;
Alveolar macrophages ;
Prostaglandins ;
Bronchoalveolar lavage fluid ;
Microbial colony count ;
Mortality ;
Reprints ;
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB93-236354 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
18p |
| Abstract |
Exposure to ozone (O3) has been shown to increase susceptibility of mice to bacterial infection; however, the underlying mechanism has not been well elucidated. The study investigated the effect of O3 exposure on the ability of mice to combat an infectious challenge of Streptococcus zooepidemicus. Following a 3-h exposure to either air, 0.4 ppm O3, or 0.8 ppm O3, 5- and 9-week-old mice received an aerosol infection of bacteria. Intrapulmonary killing of the bacteria was impaired in the O3-exposed mice. The effect was most severe at the higher dose of O3 in the younger mice, and showed good correlation to subsequent mortality assessed over a 20-day period. Alveolar macrophages (AM) from O3-exposed mice had an impaired ability to phagocytose the bacteria. Additionally, prostaglandin E2 (PGE2) levels, which are known to depress AM function, were increased in the bronchoalveolar lavage fluid of the younger mice following exposure to O3, while pretreatment with indomethacin in the drinking water blunted the increased of PGE2 and reduced O3 enhanced mortality from 53 to 33%. The data show that O3 inhalation can reduce the defensive capability of the murine lung and that this is associated with a reduction in AM phagocytosis. (Copyright (c) 1993 Taylor & Francis.) |
| Supplementary Notes |
Pub. in Experimental Lung Research, v19 n2 p299-314 May 93. See also PB84-101757. Prepared in cooperation with North Carolina Univ. at Chapel Hill. Center for Environmental Medicine and Lung Biology. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Factors That Influence the Suppression of Pulmonary Antibacterial Defenses in Mice Exposed to Ozone. |
| Category Codes |
68A; 57K; 57Y |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
330925744 |
| Origin |
NTIS |
| Type |
CAT |
