| Main Title |
Genotoxic Assessment of Environmental Tobacco Smoke Using Bacterial Bioassays. |
| Author |
Claxton, L. D. ;
Morin, R. S. ;
Hughes, T. J. ;
Lewtas, J. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div. ;Army Health Services Command, Fort Sam Houston, TX. ;Research Triangle Inst., Research Triangle Park, NC. |
| Publisher |
c1989 |
| Year Published |
1989 |
| Report Number |
EPA/600/J-89/014; |
| Stock Number |
PB89-236327 |
| Additional Subjects |
Mutagens ;
Mutations ;
Biological assay ;
Salmonella typhimurium ;
Toxic substances ;
Tobacco smoke pollution ;
Indoor air pollution ;
Mutagenicity tests
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB89-236327 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
21p |
| Abstract |
The paper demonstrates that integrated chemical and bacterial mutagenicity information can be used to identify environmental tobacco smoke genotoxicants, monitor human exposure, and make comparative assessments. Approximately one-third of the environmental tobacco smoke constituents for which there is quantitative analytical chemistry information also have associated genotoxicity information. For example, 11 of the quantitated compounds are animal carcinogens. Work presented in this paper demonstrates that both the nonparticle-bound semi-volatile and the particulate-bound organic material contain bacterial mutagens. These environmental tobacco smoke organics give an equivalent of about 86,000 revertants per cigarette. In addition, this article summarizes efforts to estimate environmental tobacco smoke bacterial mutagenicity, to use bacterial tests for the monitoring of environmental tobacco smoke-impacted indoor environments, and to use bacterial assays for the direct monitoring of human exposure. (Copyright (c) 1989 Elsevier Science Publishers B.V. (Biomedical Division).) |
| Supplementary Notes |
Pub. in Mutation Research, v222 p81-99, 1989. Prepared in cooperation with Army Health Services Command, Fort Sam Houston, TX., and Research Triangle Inst., Research Triangle Park, NC. |
| NTIS Title Notes |
Journal article. |
| Category Codes |
68A; 57Y; 57F; 57K |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
931317638 |
| Origin |
NTIS |
| Type |
CAT |
