||In vitro Mammalian Mutagenesis as a Model for Genetic Lesions in Human Cancer.
Hozier, J. ;
Applegate, M. ;
Moore, M. M. ;
||Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div. ;Florida State Univ., Tallahassee. Dept. of Biological Science. ;Florida Inst. of Tech., Melbourne. Medical Genetics Lab.
Mutagenicity tests ;
DNA mutational analysis ;
DNA probes ;
Cultured cells ;
Genetic markers ;
Genetic models ;
In vitro analysis ;
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||Molecular and cytogenetic analysis of mutations induced by a variety of genotoxic compounds at the heterozygous thymidine kinase locus in mouse lymphoma cells indicates that in vitro assay does indeed register the range of genetic lesions recently found in a wide variety of human tumors. The types and complexity of the induced lesions are reflected in mutant cell colony phenotype in a compound-specific fashion. These studies point to the use of appropriate in vitro mammalian mutagenesis assays as new model systems for dissecting the genetic lesions important to human carcinogenesis, and as a means of determining the potential for compounds to induce such lesions. (Copyright (c) 1992 Elsevier Science Publishers B.V.)
||Pub. in Mutation Research 270, n2 p201-209, 16 Nov 92. Prepared in cooperation with Florida State Univ., Tallahassee. Dept. of Biological Science, and Florida Inst. of Tech., Melbourne. Medical Genetics Lab.
|NTIS Title Notes
||Reprint: In vitro Mammalian Mutagenesis as a Model for Genetic Lesions in Human Cancer.
||PC A02/MF A01