| Main Title |
Factors to Be Considered in a Dosimetry Model for Risk Assessment of Inhaled Particles. |
| Author |
Martonen, T. ;
Hofmann, W. ;
|
| CORP Author |
Salzburg Univ. (Austria).;Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1986 |
| Report Number |
EPA-68-02-2566; EPA/600/J-86/469; |
| Stock Number |
PB88-233952 |
| Additional Subjects |
Air pollution ;
Particulates ;
Risk ;
Carcinogens ;
Models ;
Radon ;
Dosimetry ;
Reprints ;
Bronchogenic carcinoma ;
Carcinogenesis
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB88-233952 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
10p |
| Abstract |
Clinical findings suggest that bronchogenic tumors have a predilection for certain airway locations in man. Aerosol deposition studies with laryngeal-tracheobronchial casts and models indicate that such sites in situ correspond to 'hot spots' of deposition, and that cells located at carinal ridges may be particularly susceptible to development of bronchial carcinomas. For cigarette smokers, the etiology of lung cancer may be affected by synergistic interactions following exposures to naturally occurring indoor radon progeny. The problem is exacerbated for workers in the uranium mining and milling industry due to additional exposures to radioactive dust particles. The paper suggests that heterogeneous local deposition patterns in bronchial airways, concomitant with increased radiation exposure to targeted cells, may be the relevant factor in lung cancer induction, and implies that enhanced activity sites should be accounted for in risk assessment carcinogenesis models. |
| Supplementary Notes |
Pub. in Radiation Protection Dosimetry, v15 n4 p225-232 1986. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Factors to Be Considered in a Dosimetry Model for Risk Assessment of Inhaled Particles. |
| PUB Date Free Form |
c1986 |
| Category Codes |
68A; 68G; 57O |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
827422079 |
| Origin |
NTIS |
| Type |
CAT |
