| Main Title |
Statistical methods for estimating risk for exposure above the reference dose / |
| Author |
Knauf, Linda A. ;
Hertzberg, R. C.
|
| Other Authors |
|
| CORP Author |
Computer Sciences Corp., Cincinnati, OH.;Environmental Protection Agency, Cincinnati, OH. Environmental Criteria and Assessment Office. |
| Publisher |
U.S. Environmental Protection Agency, Office of Research and Development, Environmental Criteria Assessment, |
| Year Published |
1990 |
| Report Number |
EPA/600/8-90/065; EPA-68-01-7176 |
| Stock Number |
PB90-261504 |
| Subjects |
Environmental toxicology ;
Dose-response relationship (Biochemistry) ;
Pollutants--Toxicology
|
| Additional Subjects |
Toxicity ;
Statistical analysis ;
Regression analysis ;
Mathematical models ;
Exposure ;
Dieldrin ;
Nephritis ;
Risk assessment ;
Environmental pollution ;
Dose-response relationships ;
Computer applications ;
Hexachlorobenzene
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB90-261504 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
104 pages ; 28 cm |
| Abstract |
A statistical method has been developed that provides a risk estimate for noncarcinogenic effects at a given dose. The method uses a categorical regression procedure to model severity of effect as it relates to experimental dose. Toxicity data are analyzed from multiple animal experiments that span different species, target organs, toxic effects, and exposure conditions. The data are screened for homogeneity with respect to experiment duration and route of exposure. The resulting dose-response curve provides an estimate of the risk of adverse effects that may be useful in estimating risk for exposures above the reference dose (RfD). |
| Notes |
Caption title. "EPA/600/8-90/065." "August 1990." Includes bibliographical references. Microfiche. |
| Place Published |
Cincinnati, OH : |
| Supplementary Notes |
Sponsored by Environmental Protection Agency, Cincinnati, OH. Environmental Criteria and Assessment Office. |
| Corporate Au Added Ent |
United States. Environmental Protection Agency. Office of Rearch and Development. ; Environmental Criteria and Assessment Office. ; Computer Sciences Corporation. |
| PUB Date Free Form |
{1990} |
| NTIS Prices |
PC A06/MF A01 |
| BIB Level |
m |
| Cataloging Source |
OCLC/T |
| OCLC Time Stamp |
20001213113930 |
| Language |
eng |
| Origin |
NTIS |
| Type |
MERGE |
| OCLC Rec Leader |
01348nam 2200325Ka 45020 |
