| Main Title |
Inflammation in the Pathogenesis of Chronic Diseases The COX-2 Controversy / [electronic resource] : |
| Type |
EBOOK |
| Author |
Harris, Randall E.
|
| Other Authors |
| Author |
Title of a Work |
| Bittman, R. |
| Dasgupta, D. |
| Engelhardt, H. |
| Flohe, L. |
| Herrmann, H. |
| Holzenburg, A. |
| Nasheuer, H-P. |
| Rottem, S. |
| Wyss, M. |
| Zwickl, P. |
|
| Publisher |
Springer Netherlands, |
| Year Published |
2007 |
| Call Number |
RC261-271 |
| ISBN |
9781402056888 |
| Subjects |
Medicine ;
Oncology ;
Immunology ;
Neurosciences ;
Cardiology ;
Neurology ;
Pathology
|
| Internet Access |
|
| Collation |
XIII, 323 p. online resource. |
| Notes |
Due to license restrictions, this resource is available to EPA employees and authorized contractors only |
| Contents Notes |
Historical Perspectives -- Anti-Inflammatory Drugs in the 21st Century -- Inflammatory Mechanisms of Pathogenesis -- Nitric Oxide Synthase and Cyclooxygenase Interactions in Cartilage and Meniscus -- Obesity, Inflammation, and Vascular Disease -- Cyclooxygenase-2 (COX-2) and the Inflammogenesis of Cancer -- Role of COX-2 in Inflammatory and Degenerative Brain Diseases -- Inflammation and Cardiovascular Disease: The Coxib Controversy -- Cardiovascular Effects of the Selective Cyclooxygenase-2 Inhibitors -- COX-2 Inhibitors And Cardiovascular Risk -- A Biological Rationale for the Cardiotoxic Effects of Rofecoxib -- Cox-2 Blockade in Cancer Prevention and Therapy -- Cancer Chemoprevention by Cyclooxygenase 2 (COX-2) Blockade -- Strategies for Colon Cancer Prevention -- Inflammation and Neurodegenerative Disease -- NSAIDs for the Chemoprevention of Alzheimer's Disease -- Inflammation in parkinson's disease -- Nutrition, Inflammation and Chronic Disease -- Essential Polyunsaturated Fatty Acids, Inflammation, Atherosclerosis and Cardiovascular Diseases -- Nutritional Intervention in Brain Aging. In "Inflammation in the Pathogenesis of Chronic Diseases: The COX-2 Controversy", a panel of leading experts chronicles the evidence supporting the roleofinflammationinthepathogenesisofmajorchronicdiseasesanddiscusses the current controversy regarding beneficial versus adverse effects of selective cyclooxygenase-2(COX-2)inhibitors.Expertsinmultipledisciplinesofmedical research provide exciting and enlightening perspectives on COX-2 and related molecular targets in the future of medicine. The book is broadly divided into fivesections. Webeginwithhistoricalperspectivesonthediscoveryanddev- opment of aspirin, ibuprofen, and compounds that selectively inhibit COX-2, including discussion of risk versus benefit and the potential for development of new compounds with better efficacy and safety in the 21st century. This is followed by a section illuminating the role of inflammatory mechanisms in the pathogenesisofarthritis,cardiovasculardisease,cancer,neurodegenerativedisease, diabetes mellitus, obesity, and other life-threatening and debilitating conditions. Specific chapters then explore the "COX-2 controversy" regarding the potential forpositiveversusnegativeimpactofselectiveCOX-2inhibitorsonthecard- vasculature.Recentfindingssuggestthatcardiovascularriskassociatedwithsome COX-2 inhibitors may not be due to a class effect involving COX-2 inhibition, butratherdependsuponthemolecularstructureofspecificcompoundsthathave independenteffectsunrelatedtoCOX-2andprostaglandinbiosynthesis.Important findingsaredocumentedincancerresearchshowingthatselectiveCOX-2inhibitors havepowerfulantineoplasticeffectsagainstmajorformsofcancer.Aspecialsection exploresthecurrentevidencesupportingtheroleofCOX-2andinflammationinthe development of Alzheimer's disease and other neurodegenerative conditions and thepotentialbenefitofcompoundsthatmodulateCOX-2andotherinflammatory cytokines.Thefinalsectionaddressesnutritionalmodulationofinflammationinthe pathogenesisofchronicdiseaseandthechemopreventivevalueofanti-inflammatory nutraceuticalagents. |
| Place Published |
Dordrecht |
| Corporate Au Added Ent |
SpringerLink (Online service) |
| Title Ser Add Ent |
Subcellular Biochemistry, 42 |
| Host Item Entry |
Springer eBooks |
| PUB Date Free Form |
2007 |
| Series Title Untraced |
Subcellular Biochemistry, 42 |
| BIB Level |
m |
| Medium |
computer |
| Content |
text |
| Carrier |
online resource |
| Cataloging Source |
OCLC/T |
| OCLC Time Stamp |
20140518163001 |
| Language |
eng |
| Origin |
SPRINGER |
| Type |
EBOOK |
| OCLC Rec Leader |
05335nam a22006615i 45 |
