| Main Title |
Incorporation and Disappearance of Oxygen-18 in Lung from Mice Exposed to 1 PPM (18)03(1). |
| Author |
Santrock, J. ;
Hatch, G. E. ;
Slade, R. ;
Hayes, J. M. ;
|
| CORP Author |
Indiana Univ. at Bloomington. Dept. of Chemistry.;Health Effects Research Lab., Research Triangle Park, NC. |
| Publisher |
c1989 |
| Year Published |
1989 |
| Report Number |
EPA/600/J-89/235; |
| Stock Number |
PB90-145954 |
| Additional Subjects |
Ozone ;
Lung ;
Oxygen isotopes ;
Exposure ;
Mice ;
Respiration ;
Reprints ;
Air pollution effects(Animals)
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB90-145954 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
8p |
| Abstract |
In the study, (18)O(3) was used as a tracer for inhaled ozone in mice. The amount of ozone-derived oxygen (ODO) in the lungs was determined by measuring the amount of oxygen-18 in excess of the natural abundance level which remained covalently bound to organic constituents of lung tissue following exposure to 1 ppm (18)O(3). The rate of disappearance of ODO from the lungs was determined by quantifying the rate of decrease of oxygen-18 in excess of the natural abundance level in lung tissue from mice exposed to 1 ppm (18)O(3) for 45 min. With exposure to 1 ppm (18)O(3), ozone-derived oxygen accumulated in lung tissue at a rate of 4.38 pmoles of ODO/mg/min. ODO had a half-life in lung tissue of approximately 6 h. It was impossible to determine accurately the 'dose' of ozone to tissue from these data. However, it was estimated that in each animal a minimum of 44 pmoles of O(3) reacted with molecular constituents of lung tissue every minute of exposure to 1 ppm O(3). (Copyright (c) 1989 by Academic Press, Inc.) |
| Supplementary Notes |
Pub. in Toxicology and Applied Pharmacology, v98 p75-80 1989. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Incorporation and Disappearance of Oxygen-18 in Lung from Mice Exposed to 1 PPM (18)03(1). |
| Category Codes |
57Y; 57B |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
007530335 |
| Origin |
NTIS |
| Type |
CAT |
