| Main Title |
Dermal Absorption and Disposition of 1,3-Diphenylguanidine in Rats. |
| Author |
Shah, P. V. ;
Sumler, M. R. ;
Ioannou, Y. M. ;
Fisher, H. L. ;
Hall, L. L. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC. ;National Inst. of Environmental Health Sciences, Research Triangle Park, NC. |
| Year Published |
1985 |
| Report Number |
EPA/600/J-85/226; |
| Stock Number |
PB86-118494 |
| Additional Subjects |
Skin(Anatomy) ;
Toxicology ;
Rats ;
Laboratory animals ;
Absorption ;
Distribution ;
Metabolism ;
Pathology ;
Reprints ;
Guanidine/diphenyl
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB86-118494 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
12p |
| Abstract |
Dermal absorption, distribution, and metabolism of 1,3-diphenylguanidine (DPG), widely used as an accelerator in processing rubbers and in food packaging, was studied in adult female Sprague-Dawley rats. DPG shows 10% penetration through clipped back skin of the rats in 5 days. The first-order dermal absorption rate constant as determined by least square method was 0.021 + or - 0.002 days-1 (T 1/2 = 33.6 days). Approximately 13% of the absorbed dose remained in the body in 5 days. Retention in skin, muscle, liver, intestine and fat contributed most to the body burden of DPG-derived radioactivity in 5 days. All tissues showed tissue to blood ratios greater than 1, with liver and intestine ratios of 26 at 5 days. Approximately 61% of the absorbed dose was eliminated into urine and 27% into feces in 5 days, showing rapid clearance of absorbed DPG from the body. HPLC analysis of urine revealed two major peaks (parent compound and metabolite(s)). Within 72 hr, approximately 50% of the DPG-derived radioactivity excreted in the urine was parent compound. |
| Supplementary Notes |
Prepared in cooperation with Northrop Services, Inc., Research Triangle Park, NC., and National Inst. of Environmental Health Sciences, Research Triangle Park, NC. |
| Availability Notes |
Pub. in Jnl of Toxicology and Environmental Health 15, n5 p623-633 Oct 85. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Dermal Absorption and Disposition of 1,3-Diphenylguanidine in Rats. |
| PUB Date Free Form |
c1985 |
| Category Codes |
6T; 6E; 57Y; 57O |
| NTIS Prices |
Not available NTIS |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
603115744 |
| Origin |
NTIS |
| Type |
CAT |
