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OLS Field Name OLS Field Data
Main Title Effects of Trichloroethylene Exposure on Male Reproductive Function in Rats.
Author Zenick, H. ; Blackburn, K. ; Hope, E. ; Richdale, N. ; Smith, M. K. ;
CORP Author Cincinnati Univ., OH. Coll. of Medicine.;Health Effects Research Lab., Cincinnati, OH.
Year Published 1984
Report Number EPA/600/J-84/092;
Stock Number PB84-244052
Additional Subjects Toxicology ; Exposure ; Males ; Rats ; Reprints ; Laboratory animals ; Distribution ; Metabolism ; Reprints ; Ethylene/trichloro
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB84-244052 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 18p
Abstract The present study was designed to evaluate the influences of trichloroethylene (TCE) on the reproductive system of male rats. In addition, information was obtained on the distribution and metabolism of TCE. At 100 days of age, male rats were allowed to copulate with ovariectomized, hormonally primed females and copulatory behaviors scored. Fifteen minutes post-ejaculation, females were sacrificed and ejaculate and semen plug recovered from the uterus and vagina for evaluation. These data served as a pre-exposure baseline for each animal. TCE exposure was then initiated with animals intubated with either 0, 10, 100, or 1000 mg/kg of TCE (10 males/group) for 5 days/week for 6 weeks. Copulatory behaviors and semen evaluations were conducted at Weeks 1 and 5 as well as 4 weeks post-exposure. Three males/group were sacrificed at the end of the sixth week of exposure and levels of TCE and its metabolites measured in various organs and blood.
Availability Notes Pub. in Toxicology 31, p237-250 1984.
NTIS Title Notes Journal article.
Title Annotations Reprint: Effects of Trichloroethylene Exposure on Male Reproductive Function in Rats.
PUB Date Free Form c1984
Category Codes 6T; 6E; 57Y; 57O
NTIS Prices Not available NTIS
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 435625557
Origin NTIS
Type CAT