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RECORD NUMBER: 5 OF 16

OLS Field Name OLS Field Data
Main Title Effect of Trichloroethylene on Male Sexual Behavior: Possible Opioid Role.
Author Nelson, J. L. ; Zenick, H. ;
CORP Author Cincinnati Univ., OH.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1986
Report Number EPA-R-808880; EPA/600/J-86/362;
Stock Number PB87-196796
Additional Subjects Sex behavior ; Chlorohydrocarbons ; Toxicity ; Exposure ; Rats ; Hazardous materials ; Solvents ; Reprints ; Ethylene/trichloro ; Toxic substances
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB87-196796 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 7p
Abstract Trichloroethylene (TCE) is a chlorinated hydrocarbon solvent which is widely used as an industrial degreasing agent. Workers exposed to TCE often exhibit symptoms similar to those symptoms produced by narcotics. The present studies evaluated the effects of TCE exposure on measures of male sexual behavior in rats. The data indicated the TCE (1000 mg/kg, PO) 4 hours before testing produced an increased ejaculation latency effect on male copulatory behavior. Naltrexone (2.0 mg/kg, IP) given 15 minures before testing blocked this TCE-induced effect. Animals given chronic TCE administration showed tolerance to TCE's effect by the end of two weeks. Cross-tolerance to morphine was also demonstrated at this time. Quaternary naloxone failed to block any of the TCE-induced effects. These data suggest that many of TCE's effects may be mediated via the endogenous opioid system at CNS level. (Copyright (c) Ankho International Inc.)
Supplementary Notes Pub. in Neurobehavioral Toxicology and Teratology, v8 p441-445 1986. Sponsored by Health Effects Research Lab., Research Triangle Park, NC.
NTIS Title Notes Journal article.
Title Annotations Reprint: Effect of Trichloroethylene on Male Sexual Behavior: Possible Opioid Role.
PUB Date Free Form c1986
Category Codes 57Y; 57Q
NTIS Prices PC A02/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 723225818
Origin NTIS
Type CAT