| Main Title |
Genotoxicity and Identification of the Major DNA-Adducts of Aceanthrylene. |
| Author |
Nesnow, S. ;
Ross, J. ;
Mohapatra, N. ;
Gupta, R. ;
Sangaiah, R. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Baylor Coll. of Medicine, Houston, TX. ;North Carolina Univ. at Chapel Hill. Dept. of Environmental Sciences and Engineering. |
| Year Published |
1988 |
| Report Number |
EPA/600/D-88/026; |
| Stock Number |
PB88-170071 |
| Additional Subjects |
Toxicology ;
Deoxyribonucleic acids ;
Identification ;
Genotoxicity ;
Aceanthrylene ;
Salmonella typhimurium
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB88-170071 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
15p |
| Abstract |
Aceanthrylene (ACE), a cyclopenta-fused polycyclic aromatic hydrocarbon (CP-PAH) derivative of anthracene has been shown to be highly mutagenic in Salmonella typhimurium strain TA98 (1). C3H10T1/2CL8 (C3H10T1/2) mouse embryo fibroblasts have been used to study the metabolism and morphological transforming ability of PAH and several CP-PAH (2-5). The CP-PAH, cyclopenta(cd)pyrene and three of the four possible cyclopenta-benz(a)anthracene isomers were active in morphologically transforming C3H10T1/2 cells. Cyclopenta(cd)pyrene and two of the four possible isomers of cyclopenta-benz(a)anthracene, benz(j)aceanthrylene, and benz(l)aceanthrylene, were metabolized by C3H10T1/2 cells to dihydrodiol metabolites including cyclopenta-ring dihydrodiols. The study examines the ability of ACE, the smallest linear-fused CP-PAH yet examined, to be metabolized, to form DNA adducts, and to induce morphological transformation in C3H10T1/2 mouse embryo fibroblasts. |
| Supplementary Notes |
Prepared in cooperation with Baylor Coll. of Medicine, Houston, TX., and North Carolina Univ. at Chapel Hill. Dept. of Environmental Sciences and Engineering. |
| PUB Date Free Form |
Feb 88 |
| Category Codes |
57Q; 57Y |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
812722283 |
| Origin |
NTIS |
| Type |
CAT |
