||Teratogenic Effects of the Fungicide Dinocap in the Mouse.
Rogers, J. M. ;
Carver, B. ;
Gray, L. E. ;
Gray, J. A. ;
Kaylock, R. J. ;
||Health Effects Research Lab., Research Triangle Park, NC.
Congenital abnormalities ;
Cleft palate ;
Abnormalities drug induced ;
Fetal growth retardation ;
Dose response relationship drug
||Some EPA libraries have a fiche copy filed under the call number shown.
||The teratogenic potential of the fungicide dinocap was evaluated in CD-1 mice. Pregnant mice were dosed by intubation with dinocap in corn oil on gestation days 7-16. Doses used were 0, 5, 10, 20, 40, 80, and 120 mg/kg/day, based on d 6 weight. Dams were killed on d 18, at which time fetuses were counted, weighed, and preserved for necropsy or skeletal examination. The highest dose killed 80% of the dams dosed, while 29% of the dams in the 80 mg/kg group died during dosing. There was no dose-related maternal mortality at lower doses. Net maternal weight gain was affected only at 80 mg/kg/day. There were no live fetuses at 120 mg/kg/day. The number of live fetuses per litter was decreased and resorptions increased at 80 mg/kg. This study shows that dinocap is teratogenic in the CD-1 mouse at doses well below those causing maternal toxicity.
||Pub. in Teratogenesis, Carcinogenesis, and Mutagenesis 6, p375-381 1986.
|NTIS Title Notes
||Reprint: Teratogenic Effects of the Fungicide Dinocap in the Mouse.
|PUB Date Free Form
||PC A02/MF A01