| Main Title |
Methoxychlor Affects the Decidual Cell Response of the Uterus but Not Other Progestational Parameters in Female Rats (Journal Version). |
| Author |
Cummings, A. M. ;
Gray, L. E. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
| Publisher |
1987 |
| Year Published |
1987 |
| Report Number |
EPA/600/J-87/407; |
| Stock Number |
PB89-105530 |
| Additional Subjects |
Hydrocarbons ;
Cells(Biology) ;
Rats ;
Insecticides ;
Uterus ;
Chlorohydrocarbons ;
Reproduction(Biology) ;
Dosage ;
Pregnancy ;
Responses ;
Fertility ;
Chlorine aliphatic compounds ;
Evaluation ;
Estrone ;
Reprints ;
Methoxychlor
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB89-105530 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
10p |
| Abstract |
The pesticide methoxychlor (MXC) is a proestrogen which is metabolized to a compound that has been shown to exhibit estrogenic activity in vivo and in vitro. Following long-term exposure of female rats to MXC, fertility is reduced and fetotoxicity is evident. However, the effects of MXC on several aspects of maternal reproductive physiology including the decidual cell response (DCR), ovarian weight, serum progester-one levels, and corpora lutea maintenance, have not been previously described. In the present study, the ability of MXC to interfere with progestational events essential for implantation and the maintenance of pregnancy in the rat was investigated. MXC was administered to pseudopregnant rats, decidualization was induced on day 4, and the DCR and related parameters were evaluated following sacrifice on day 9. DCR induction during estrone adminstration served as a positive control. |
| Supplementary Notes |
Pub. in Toxicology and Applied Pharmacology, v90 p330-336 1987. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Methoxychlor Affects the Decidual Cell Response of the Uterus but Not Other Progestational Parameters in Female Rats (Journal Version). |
| Category Codes |
68E; 68G; 57Y; 57E |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
833027469 |
| Origin |
NTIS |
| Type |
CAT |
