| Main Title |
Developmental Toxicity of Dinocap in the Mouse is not Due to Two Isomers of the Major Active Ingredients (Journal Version). |
| Author |
Rogers, J. M. ;
Gray, L. E. ;
Carver, B. D. ;
Kavlock, R. J. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
| Publisher |
1987 |
| Year Published |
1987 |
| Report Number |
EPA/600/J-87/415; |
| Stock Number |
PB89-105852 |
| Additional Subjects |
Toxic substances ;
Fungicides ;
Teratogens ;
Fetus ;
Isomers ;
Laboratory animals ;
Nitrogen organic compounds ;
Prenatal exposure delayed effects ;
Pregnancy ;
Cleft palate ;
Fetal viability ;
Body weight ;
Otoliths ;
Reprints ;
Dinocap ;
Butenoic acid/methyheptyl-dinitrophenyl ester
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB89-105852 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
8p |
| Abstract |
The developmental toxicities of 2,4-dinitro-6-(1-methylheptyl)phenyl crotonate and 2,6-dinitro-4-(1-methylheptyl)phenyl crotonate, model isomers of the major active ingredients of technical dinocap, were compared to the known teratogenicity of the technical compound. Individual isomers, both isomers combined, or technical dinocap were administered to pregnant mice on days 7-16 of gestation. Similar to previous studies, technical grade dinocap caused cleft palate and weight deficits in fetuses at term and increased neonatal mortality and abnormal swimming behavior, torticollis, and deficient otolith formation in surviving pups. Neither of the purified isomers exhibited any developmental toxicity when administered under identical conditions. Thus, it is concluded that these isomers are not the active teratogenic component(s) in technical grade dinocap. |
| Supplementary Notes |
Pub. in Teratogenesis, Carcinogenesis, and Mutagenesis, v7 p341-346 1987. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Developmental Toxicity of Dinocap in the Mouse Is Not Due to Two Isomers of the Major Active Ingredients (Journal Version). |
| Category Codes |
57Y; 57U; 44G; 68E; 68G |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
833027548 |
| Origin |
NTIS |
| Type |
CAT |
