Main Title |
Effects of Lindane and Linuron on Calcium Metabolism, Bone Morphometry and the Kidney in Rats. |
Author |
Andrews, J. E. ;
Gray, L. E. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
Publisher |
c1990 |
Year Published |
1990 |
Report Number |
EPA/600/J-90/047; |
Stock Number |
PB90-217480 |
Additional Subjects |
Chlorobenzenes ;
Calcium ;
Metabolism ;
Toxicology ;
Bones ;
Kidney ;
Hormones ;
Body weight ;
Tables(Data) ;
Blood chemical analysis ;
Urine ;
Reprints ;
Linuron ;
Organ weight
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB90-217480 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
11p |
Abstract |
The effects of lindane and linuron on calcium metabolism, bone morphometry and the kidney. Experiments were performed to investigate the effects of lindane and linuron on calcium metabolism, femur morphometry and nephrotoxicity. Long-Evans hooded rats were dosed daily for 10 weeks with 0, 10 or 20 mg lindane or 10, 20 or 40 mg linuron/kg body weight beginning at weaning. Lindane significantly decreased urinary calcium concentration, serum alkaline phosphatase concentration and the cross-sectional medullary area of the bone. Lindane was nephrotoxic at both dose levels as demonstrated by elevated kidney weights, kidney-to-body-weight ratios, enzymuria, tubule regeneration and hyaline droplet degeneration. Linuron significantly reduced medullary cross-sectional area at the two higher dose levels and decreased the total femur cross-sectional area at the highest dose level in the absence of effects on calcium excretion. Femur density and strength were also significantly reduced at the highest dose level of linuron. Neither compound affected the serum concentrations of parathyroid hormone or 1,25-dihydroxy Vitamin D3. |
Supplementary Notes |
Pub. in Toxicology, v60 p99-107 Jan 90. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Effects of Lindane and Linuron onCalcium Metabolism, Bone Morphometry and the Kidney in Rats. |
Category Codes |
57Y; 57S |
NTIS Prices |
PC A03/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
019411165 |
Origin |
NTIS |
Type |
CAT |