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OLS Field Name OLS Field Data
Main Title Increased Pulmonary Disease Mediated through Altered Bacterial Defenses.
Author Gardner, Donald E. ; Graham., Judith A. ;
CORP Author Health Effects Research Lab., Research Triangle Park, N.C. Clinical Studies Div.
Year Published 1977
Report Number EPA/600/J-77/094;
Stock Number PB-278 586
Additional Subjects Respiratory diseases ; Immunology ; Lung ; Immunity ; Phagocytes ; Bacteria ; Air pollution ; Ozone ; Nitrogen ; Trace elements ; Toxicology ; Laboratory animals ; Experimental data ; Reprints ; Immunosuppression ; Muramidase ; Macrophages ; Pulmonary surfactants ; Air pollution effects(Humans)
Library Call Number Additional Info Location Last
NTIS  PB-278 586 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 25p
Abstract The process of infection has been defined as an interaction of a host, a microbe, and the environment. In the natural environment, healthy individuals exist in equilibrium with potentially pathogenic microorganisms. Using this concept, an animal-model system was developed to study the effects of pollutants that can affect this equilibrium and result in acute pulmonary disease. Increase of mortality from exposure to several pathogenic organisms has been reported for a variety of animal species after exposure to ozone, nitrogen dioxide, and a variety of trace metals. There are a number of possible mechanisms by which the lung can become more vulnerable to microorganisms. These include (1) reduction in deposition or retention of bacteria, (2) slowing of physical removal of bacterial cells by the mucociliary mechanisms, (3) dysfunction of the alveolar macrophages, (4) alteration of the acellular lining material (surfactant) of the deep lung, (5) the presence of edema fluid or inflammatory exudate in the airway, and (6) pulmonary immunosuppression. The influence of environmental pollutants on each of these factors is discussed.
Supplementary Notes Pub. in Pulmonary Macrophage and Epithelial Cells, ERDA Symposium Ser-43, pl-20. Proceedings of the Annual Hanford Biology Symposium (16th), Richland, Wash. 27-29 Sep 76, 1977.
NTIS Title Notes Journal article.
Title Annotations Reprint: Increased Pulmonary Disease Mediated through Altered Bacterial Defenses.
PUB Date Free Form 1977
Category Codes 6E; 6T; 68G; 68A; 57E; 57J; 57Y
NTIS Prices PC A02/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 323736908
Origin NTIS
Type CAT