| Main Title |
Influence of Ozone on Xenobiotic Metabolism. |
| Author |
Graham, Judith A. ;
Menzel, Daniel B. ;
Miller, Frederick J. ;
Illing, Joseph W. ;
Ward, Robert ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Duke Univ., NC. ;Northrop Services, Inc., Research Triangle Park, NC. |
| Year Published |
1983 |
| Report Number |
EPA-600/D-83-063; |
| Stock Number |
PB83-243238 |
| Additional Subjects |
Ozone ;
Toxicology ;
Metabolism ;
Mice ;
Females ;
Physiological effects ;
Exposure ;
Sensitivity ;
Concentration(Composition) ;
Sleep ;
Drugs ;
Paralysis ;
Pentobarbital ;
Inhibitors ;
Enzymes ;
Air pollution effects(Animals) ;
Pharmacokinetics
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB83-243238 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
17p |
| Abstract |
Gardner et al. found that ozone (O3) exposure increased pentobarbital induced sleeping time in female CD-1 mice. The animals were exposed to 1960 micrograms O3/cu. m (1 ppm) for 3 hr/day for up to 7 days, but an effect was only observed on the second and third day of exposure. Since animals awake from PEN-induced S.T. because of hepatic xenobiotic metabolism, it was hypothesized that O3 exposure resulted in effects that occured in the liver, making investigations to elucidate the mechanisms involved of interest. To this end, a series of studies were performed which are summarized in the report. |
| Supplementary Notes |
Prepared in cooperation with Duke Univ., NC. and Northrop Services, Inc., Research Triangle Park, NC. |
| PUB Date Free Form |
1983 |
| Category Codes |
6T; 6F; 57Y; 68A |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
332921482 |
| Origin |
NTIS |
| Type |
CAT |
