| Main Title |
Effect of Sodium Pentobarbital on Behavioral Thermoregulation in Rats and Mice. |
| Author |
Strek, K. S. ;
Long, M. D. ;
Gordon, C. J. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1986 |
| Report Number |
EPA/600/J-86/176; |
| Stock Number |
PB87-115101 |
| Additional Subjects |
Thermoregulation ;
Drugs ;
Behavior ;
Rats ;
Mice ;
Laboratory animals ;
Reprints ;
Sodium pentobarbital
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB87-115101 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
6p |
| Abstract |
The experiment was designed to study the effects of sodium pentobarbital on behavioral thermoregulation in rats and mice. Male Sprague-Dawley rats were given intraperitoneal (i.p.) injections of sodium pentobarbital in doses of 0, 1, 5, 10 or 15 mg/kg and male CBA/J mice were given doses of 0, 5, 10, 15 or 30 mg/kg. The animals were immediately placed in a temperature gradient which allowed them to select their preferred ambient temperature (Ta). The preferred Ta of rats increased following a 10 mg/kg injection of sodium pentobarbital. However, the barbiturate had no effect on the preferred Ta of mice. The data suggest a peripheral action of sodium pentobarbital in rats which results in hypothermia and an appropriate compensatory behavioral selection of a warmer Ta. |
| Supplementary Notes |
Pub. in Pharmacology, Biochemistry and Behavior, v24 n4 p1147-1150 Apr 86. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Effect of Sodium Pentobarbital on Behavioral Thermoregulation in Rats and Mice. |
| PUB Date Free Form |
1986 |
| Category Codes |
57Q |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
703715363 |
| Origin |
NTIS |
| Type |
CAT |
