| Main Title |
Strain Comparisons of DFP Neurotoxicity in Rats. |
| Author |
Gordon, C. J. ;
MacPhail, R. C. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. |
| Publisher |
c1993 |
| Year Published |
1993 |
| Report Number |
EPA/600/J-93/354; |
| Stock Number |
PB93-228609 |
| Additional Subjects |
Isoflurophate ;
Toxicity ;
Nervous system ;
Cholinesterase inhibitors ;
Species diversity ;
Rats ;
Cholinesterase ;
Body temperature ;
Motor activity ;
Pesticides ;
Dose-response relationships ;
Graphs(Charts) ;
Reprints ;
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB93-228609 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
15p |
| Abstract |
The purpose of the study was to assess intraspecies differences in behavioral and autonomic function in three strains of rat following administration of diisopropyl fluorophosphate (DFP), an irreversible inhibitor of acetylcholinesterase activity. Male rats of the Long-Evans (LE), Fischer 344 (F344), and Sprague-Dawley (SD) strains were administered DFP at doses of 0 to 1.5 mg/kg (s.c.). The animals were placed 60 min later into one of two motor activity chambers and tested for 30 min. Motor activity was measured using either a Doppler-based system or a commercial photocell device. Following measurement of motor activity in the Doppler system, body temperature was measured and blood was then withdrawn by cardiac puncture and analyzed for serum cholinesterase activity. The remaining rats were retested 24 hr after DFP administration in the photocell device. The results showed a significant influence of strain on the effects of DFP. Motor activity of LE rats was reduced by DFP at doses of 1.0 and 1.5 mg/kg, whereas the activity of F344 rats was reduced only at 1.5 mg/kg. |
| Supplementary Notes |
Pub. in Jnl. of Toxicology and Environmental Health 38, p257-271 Mar 93. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Strain Comparisons of DFP Neurotoxicity in Rats. |
| Category Codes |
57Y; 68E |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
329432243 |
| Origin |
NTIS |
| Type |
CAT |
