Main Title |
Toxic-Induced Hypothermia and Hypometabolism: Do They Increase Uncertainty in the Extrapolation of Toxicological Data from Experimental Animals to Humans. |
Author |
Gordon, C. J. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
Publisher |
1991 |
Year Published |
1991 |
Report Number |
EPA/600/J-91/045; |
Stock Number |
PB91-191528 |
Additional Subjects |
Toxic substances ;
Hypothermia ;
Animal disease models ;
Rats ;
Mice ;
Risk assessment ;
Body weight ;
Toxicity ;
Body temperature ;
Reprints ;
Hypometabolism
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB91-191528 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
7p |
Abstract |
Commonly used experimental mammals, such as the rat and mouse, exhibit hypothermia and hypometabolism when exposed acutely to many drugs and other chemical substances. This toxic-induced hypothermic/hypometabolic state may be an inherently protective response that can reduce the lethality of a toxic insult. However, as body mass increases, the ability to lower body temperature in response to toxic insult is diminished. Hence, the presence of a protective hypometabolic/hypothermic response in small laboratory mammals and apparent lack thereof in larger species, such as humans, may represent an additional physiological dissimilarity which may underestimate the risk assessment of acute toxicological data. |
Supplementary Notes |
Pub. in Neuroscience and Biobehavioral Reviews, v15 n1 p95-98 Jan 91. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Toxic-Induced Hypothermia and Hypometabolism: Do They Increase Uncertainty in the Extrapolation of Toxicological Data from Experimental Animals to Humans. |
Category Codes |
57Y; 57S |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
119326265 |
Origin |
NTIS |
Type |
CAT |