| Main Title |
Effect of Nickel and Cadmium Chloride on Autonomic and Behavioral Thermoregulation in Mice. |
| Author |
Gordon, C. J. ;
Stead, A. G. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1986 |
| Report Number |
EPA/600/J-86/449; |
| Stock Number |
PB88-171103 |
| Additional Subjects |
Toxicology ;
Nickel chloride ;
Cadmium chloride ;
Thermoregulation ;
Mice ;
Laboratory animals ;
Reprints ;
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB88-171103 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
12p |
| Abstract |
Male BALB/c mice were injected intraperitoneally (i.p.) with nickel chloride (0, 5, 10, and 15 mg/kg) or cadmium chloride (0, 2, 4, and 6 mg/kg) while preferred ambient temperature (Ta) and activity were measured. Both metals caused drastic reductions in preferred Ta and activity within 30 min postinjection. Preferred Ta and activity were depressed for up to 90 min following nickel and cadmium injection. In a second experiment, body temperature was measured 60 min following the injection of nickel or cadmium chloride at a Ta of 20, 30, or 35 C. Nickel and cadmium caused a drastic reduction in body temperature when injected at a Ta of 20 and 30 C but produced either no effect or only a slight elevation in body temperature at a Ta of 35 C. In a third experiment, metabolic rate was measured continuously for 60 min following the i.p. injection of a relatively large dose of nickel (15 mg/kg) or cadmium chloride (6 mg/kg) at a Ta of 20, 30, and 35 C. Both metals caused significant reductions in metabolic rate at Ta's of 20 and 30 C. |
| Supplementary Notes |
Pub. in Neurotoxicology-7, n3 p97-106 1986. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Effect of Nickel and Cadmium Chloride on Autonomic and Behavioral Thermoregulation in Mice. |
| PUB Date Free Form |
1986 |
| Category Codes |
57Y |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
812722826 |
| Origin |
NTIS |
| Type |
CAT |
