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OLS Field Name OLS Field Data
Main Title Synaptonemal Complex Damage as a Measure of Genotoxicity at Meiosis.
Author Allen, J. W. ; Poorman, P. A. ; Backer, L. C. ; Gibson, J. B. ; Westbrook-Collins, B. ;
CORP Author Burroughs Wellcome Co., Research Triangle Park, NC. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC. ;Duke Univ. Medical Center, Durham, NC.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1988
Report Number EPA-R-812736; EPA/600/D-88/136;
Stock Number PB88-223789
Additional Subjects Toxicity ; Genes ; Meiosis ; Cell division ; Chromosomes ; Mitomycins ; Cyclophosphamide ; Colchicine ; Vinblastine ; Laboratory animals ; Mice ; Chromosomal aberrations ; Genetic disorders ; Genotoxicity ; Duplication(Genes) ; Amsacrine ; Ellipticines ; Cisplatin ; Chromosome damage ; Synaptonemal complex
Library Call Number Additional Info Location Last
NTIS  PB88-223789 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 12/29/1988
Collation 17p
Abstract Synaptonemal complex aberrations can provide a sensitive measure of chemical-specific alterations to meiotic chromosomes. Mitomycin C, cyclophosphamide, amsacrine, ellipticine, colchicine, vinblastine sulfate, and cis-platin exposures in mice have been shown to cause various patterns of synaptonemal complex structural damage and synaptic irregularity. These effects are suggestive of abnormal homologue pairing/synapsis/recombination effects which, theoretically, could be implicated in mechanisms leading to aneuploidy and other potentially heritable chromosomal disorders.
Supplementary Notes Prepared in cooperation with Environmental Health Research and Testing, Inc., Research Triangle Park, NC., and Duke Univ. Medical Center, Durham, NC. Sponsored by Health Effects Research Lab., Research Triangle Park, NC.
PUB Date Free Form Jun 88
Category Codes 57F
NTIS Prices PC A03/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 826017170
Origin NTIS
Type CAT