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Main Title

Mutagenicity and carcinogenicity assessment of 1,3-butadiene.

Author

Bayard, S. ; Beliles, R. P. ; Chiu, A. ; Gibb, H. J. ; Sadler, B.

CORP Author

United States. Environmental Protection Agency. Office of Health and Environmental Assessment.

Publisher

Office of Health and Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency,

Year Published

1985

Report Number

EPA-600/8-85-004 F; EPA-600/8-85-004 A

Stock Number

PB86-125507; PB85-181097

OCLC Number

12960165

Subjects

Butadiene--Toxicology ; Carcinogens ; Mutagens ; Environmental health

Additional Subjects

Butadiene--Toxicology ; Carcinogens ; Mutagens ; Environmental health ; Environmental surveys ; Industrial medicine ; Rubber industry ; Laboratory animals ; Exposure ; Toxicity ; Inspection ; Hazardous materials ; Air pollution ; Risk ; Butadienes ; Chemical analysis ; Styrene butadiene resin ; Ventilation ; Assessments ; Dosage ; Bacteria ; In vivo analysis ; Toxic substances ; Occupational safety and health ; Indoor air pollution ; Salmonella typhimurium ; Styrene butadiene resins

Internet Access

Description	Access URL
EPA 600/8-85-004F	https://nepis.epa.gov/Exe/ZyPDF.cgi?Dockey=30001EUB.PDF
EPA 600/8-85-004A	https://nepis.epa.gov/Exe/ZyPDF.cgi?Dockey=2000ADA9.PDF

Holdings

Library	Call Number	Additional Info	Location	Last Modified	Checkout Status
EHAM	RA1247.B8 EPA-600 8-85 -004F		Region 1 Library/Boston,MA	04/29/2016
EJBD	EPA-600/8-85-004A		Headquarters Library/Washington,DC	02/28/2007
EJED	EPA 600/8-85-004A		OCSPP Chemical Library/Washington,DC	06/14/2002
EKBD	EPA-600/8-85-004A		Research Triangle Park Library/RTP, NC	04/16/2004
EKBD	EPA-600/8-85-004F	c.1	Research Triangle Park Library/RTP, NC	08/23/2016
EKBD	EPA-600/8-85-004F	c.2	Research Triangle Park Library/RTP, NC	08/23/2016
ELBD ARCHIVE	EPA 600-8-85-004F	Received from HQ	AWBERC Library/Cincinnati,OH	10/04/2023	DISPERSAL
ERAD	EPA 600/8-85-004F		Region 9 Library/San Francisco,CA	02/26/2013
ESAD	EPA 600-8-85-004A		Region 10 Library/Seattle,WA	03/23/2010
ESAD	EPA 600-8-85-004 F		Region 10 Library/Seattle,WA	01/02/1998
NTIS	PB85-181097	Some EPA libraries have a fiche copy filed under the call number shown.		07/26/2022
NTIS	PB86-125507	Some EPA libraries have a fiche copy filed under the call number shown.		07/26/2022

Collation

1 volume (various pagings) : illustrations ; 28 cm

Abstract

1,3-Butadiene has been shown to be an indirect mutage in bacteria. Two of its potential metabolites, 3,4- epoxybutene and diepoxybutane, are genotoxic in prokaryote as well as eukaryote test systems. Exposure of rodents to 1,3-butadiene results in ovarian tumors in mice and testicular tumors in rats, which offers suggestive evidence that 1,3-butadiene (or a motabolite of 1,3-butadiene) may reach the germ cells. There is also evidence that the dimer of 1,3-butadiene, 4-vinyl-1-cyclohexene, causes ovarian tumors in mice. The total body of evidence, including metabolism, mutagenicity and carcinogenicity data, suggests that 1,3-butadiene may present a genetic risk to humans. However, mutagenicity studies in mammalian test systems should be conducted to further characterize the mutagenic potential of 1,3-butadiene. On the basis of sufficient evidence from studies in two species of rodents, and inadequate epidemiologic data, 1,3-butadiene can be classified, according to EPA's Proposed Guidelines for Carcinogen Risk Assessment, as a 'probable' human carcinogen, Group B2. Using the classification scheme of the International Agency for Research on Cancer, 1,3-butadiene would be classified as a 'probable' human carcinogen, Group 2B.

Notes

"Final report." Distributed to depository libraries in microfiche. "September 1985." Includes bibliographical references (pages 7-1-7-7). "EPA-600/8-85-004F."

Place Published

Washington, D.C.

Supplementary Notes