||Mucociliary Clearance of Inhaled Particles Measured at 2 h after Ozone Exposure in Humans.
Gerrity, T. R. ;
Bennett, W. D. ;
Kehrl, H. ;
DeWitt, P. J. ;
||Health Effects Research Lab., Research Triangle Park, NC. Human Studies Div. ;North Carolina Univ. at Chapel Hill. Center for Environmental Medicine and Lung Biology.
||25 Sep 91
Air pollution effects(Humans) ;
Respiratory function tests ;
Biological transport ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||Acute exposure of humans to ozone is known to acutely cause pulmonary function decrements, inflammation, and increased permeability of pulmonary epithelium. Fifteen healthy male and female nonsmoking subjects were exposed, on different occasions, to clean air and 0.4 ppm ozone for 1 hour while they exercised continuously. Pulmonary function was measured immediately before and after exposure and 90 min and 24 hours after exposure. Each subject returned the next day for a final particle retention measurement. Despite significant changes in pulmonary function, there was no difference in mean whole lung retention time of particles between clean air and ozone exposures, indicating that mucociliary transport is unaffected by ozone exposure when it is measured 2 hours after exposure.
||Pub. in Jnl. of Applied Physiology, v74 n6 p2984-2989 Jun 93. See also PB89-110548. Prepared in cooperation with North Carolina Univ. at Chapel Hill. Center for Environmental Medicine and Lung Biology.
|NTIS Title Notes
||Reprint: Mucociliary Clearance of Inhaled Particles Measured at 2 h after Ozone Exposure in Humans.
||68G; 68A; 57Y; 57S
||PC A02/MF A01