Main Title |
Pulmonary Clearance of Inhaled Particles 24 to 48 Hours Post Deposition: Effect of Beta-Adrenergic Stimulation. |
Author |
Bennett, W. D. ;
Chapman, W. F. ;
Lay, J. C. ;
Gerrity, T. R. ;
|
CORP Author |
North Carolina Univ. at Chapel Hill. Center for Environmental Medicine and Lung Biology.;Health Effects Research Lab., Research Triangle Park, NC. Clinical Research Branch. |
Publisher |
c10 Jul 91 |
Year Published |
1991 |
Report Number |
EPA/600/J-93/360; |
Stock Number |
PB93-228864 |
Additional Subjects |
Lung ;
Beta adrenergic receptors ;
Respiration ;
Air pollutants ;
Aerosols ;
Airway resistance ;
Detectors ;
Albuterol ;
Organotechnetium compounds ;
Reprints ;
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB93-228864 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
10p |
Abstract |
Recent studies have suggested considerable particle retention in the bronchial ciliated airways 24 hours after depositing in the lung. A significant presence of particles in the ciliated airways at 24 hours post deposition may be indicated if beta-adrenergic treatment between 24 and 48 hours is shown to enhance particle clearance during this same period. The hypothesis was tested in ten young, normal subjects who inhaled Tc99m-iron oxide particles (5 micrometers MMAD) on three separate occasions. Following the first aerosol exposure, each subject inhaled a dose of albuterol sufficient to decrease specific airway resistance by 63% and clearance was measured by gamma camera over a 3 hour period. For the subsequent two aerosol exposures, baseline mucociliary clearance was measured, again over the initial 3 hour period, and then retention of particles was monitored with a six crystal gamma detector between 24 and 48 hours. During this 24-48 hour period, each subject inhaled 2 doses of either albuterol (a similar dose to that described above) or saline (double-blinded design). Albuterol significantly enhanced clearance at one hour post deposition. |
Supplementary Notes |
Pub. in Jnl. of Aerosol Medicine, v6 n1 p53-62 Mar 93. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. Clinical Research Branch. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Pulmonary Clearance of Inhaled Particles 24 to 48 Hours Post Deposition: Effect of Beta-Adrenergic Stimulation. |
Category Codes |
57S; 68A |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
329432369 |
Origin |
NTIS |
Type |
CAT |