| Main Title |
Comparative Gastrointestinal Enzyme Activity and Activation of the Promutagen 2,6-Dinitrotoluene in Male CD-1 Mice and Male Fischer 344 Rats. |
| Author |
Chadwick, R. W. ;
George, S. E. ;
Chang, J. ;
Kohan, M. J. ;
Dekker., J. P. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;North Carolina Univ. at Chapel Hill. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC. |
| Publisher |
c1990 |
| Year Published |
1990 |
| Report Number |
EPA/600/J-90/169; |
| Stock Number |
PB91-115816 |
| Additional Subjects |
Enzymes ;
Gastrointestinal system ;
Mutagens ;
Toxicology ;
Mice ;
Rats ;
Male ;
Hepatuma ;
In vitro analysis ;
In vivo analysis ;
Metabolism ;
Bioassay ;
Reprints ;
Ditoluenes ;
Species specificity ;
Biotransformation ;
Mutagenicity tests ;
Carcinogenicity tests
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB91-115816 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
9p |
| Abstract |
Comparative intestinal nitroreductase, azo reductase, beta-glucuronidase, dechlorinase, and dehydrochlorinase activities in young male Fischer 344 rats and young male CD-1 mice were measured in vitro while the comparative biotransformation of 2, 6-dinitrotoluene to mutagenic metabolites was determined in vivo. The mice, which exhibit a high spontaneous incidence of hepatomas, had markedly greater nitroreductase activity and metabolized significantly more 2, 6-dinitrotoluene to mutagenic metabolites than did Fischer 344 rats, which show a low incidence of liver tumors. Results of this study indicate that species differences in the incidence of hepatomas may be influenced by microbial flora and/or the biotransformation of xenobiotics in the G.I. tract. (Copyright (c) Elsevier Scientific Publishers Ireland, Ltd.) |
| Supplementary Notes |
Pub. in Cancer Letters, v52 n1 p13-19 Jun 90. Prepared in cooperation with North Carolina Univ. at Chapel Hill, and Environmental Health Research and Testing, Inc., Research Triangle Park, NC. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Comparative Gastrointestinal Enzyme Activity and Activation of the Promutagen 2,6-Dinitrotoluene in Male CD-1 Mice and Male Fischer 344 Rats. |
| Category Codes |
57Y; 57F; 57B |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
101123259 |
| Origin |
NTIS |
| Type |
CAT |
