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Main Title Effects of Cadmium and Zinc on Canine Tracheal Bioelectric Properties.
Author Stutts, M. J. ; Boucher, R. C. ; Gatzy, J. T. ;
CORP Author North Carolina Univ. at Chapel Hill.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1982
Report Number EPA-600/J-82-421;
Stock Number PB84-144344
Additional Subjects Toxicology ; Cadmium ; Zinc ; Bioelectricity ; Trachea ; Respiratory system ; Dogs ; Laboratory system ; Reprints ; Heavy metals
Library Call Number Additional Info Location Last
NTIS  PB84-144344 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 11p
Abstract Euminal exposure of excised tracheal epithelium to Cd(N03)2 inhibited short circuit current by 50% and increased dc conductance 500%. Zn(NO3)2 reduced conductance by 24% but did not affect short circuit current. Exposure to both salts induced a slightly greater inhibition of short circuit current than Cd(NO3)2 alone but had no significant effect on conductance. Submucosal exposure to Cd(NO3)2 inhibited short circuit current and induced at least a 10- to 20-fold increase in conductance. The potency, compared to luminal exposure, was 10-fold greater. Submucosal Zn(N03)2 inhibited short circuit current and was about as potent as Cd(N03)2. Zn(N03)2 had little effect on conductance. Inhibition of short circuit current by submucosal Cd(N03)2 was additive and luminal but not submucosal, Zn protected against the increase in conductance induced by submucosal Cd.
Availability Notes Pub. in Toxicology and Applied Pharmacology 64, p147-154 1982.
NTIS Title Notes Journal article.
Title Annotations Reprint: Effects of Cadmium and Zinc on Canine Tracheal Bioelectric Properties.
PUB Date Free Form c1982
Category Codes 6T; 6P; 57Y; 57S
NTIS Prices Not available NTIS
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 409019547
Origin NTIS
Type CAT