| Main Title |
Toxicology of Abate in Laboratory Animals. |
| Author |
Gaines, Thomas B. ;
Kimbrough, Ranate ;
Laws, Jr., Edward R. ;
|
| CORP Author |
National Communicable Disease Center, Atlanta, Ga. |
| Year Published |
1966 |
| Stock Number |
PB-279 276 |
| Additional Subjects |
Pesticides ;
Toxicology ;
Bioassay ;
Dogs ;
Insecticides ;
Cholinesterase inhibitors ;
Phosphorus organic compounds ;
Lethal dosage ;
Rats ;
Laboratory animals ;
Dosage ;
Toxicity ;
Concentration(Composition) ;
Ingestion(Biology) ;
Mice ;
Rats ;
Rabbits ;
Signs and symptoms ;
Chickens ;
Reproduction(Biology) ;
Reprints ;
Abate ;
Toxic substances
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB-279 276 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
6p |
| Abstract |
In laboratory animals Abate produces signs, symptoms, and type of death typical of those associated with other organic phosphorus compounds. In large enough doses Abate will inhibit cholinesterase, and it does this more promptly and to a greater extent for RBC cholinesterase than for plasma cholinesterase. The acute oral lethal dose (LD50) for Abate in rats and male mice is 4,000 mg/kg or greater. Restrained female rats tolerate a dermal dose of Abate of 4,000 mg/kg without clinical effect, but the same dosage killed two of ten males. Rats, rabbits, guinea pigs, and chickens tolerate a daily oral dosage of Abate of 10 mg/kg without observable clinical effect, and dogs tolerate a daily dosage of 3 to 4 mg/kg, the highest rate at which they were dosed. Rats and rabbits tolerate at a dosage of 1 mg/kg/day for extended periods of time without detectable effect on cholinesterase. |
| Supplementary Notes |
Pub. in Archives of Environmental Health, v14 p283-288, Feb 67. |
| Availability Notes |
Included in the report, Journal Articles on Toxicology. Group 4, PB-279 272. |
| Title Annotations |
Reprint: Toxicology of Abate in Laboratory Animals, |
| PUB Date Free Form |
23 Aug 66 |
| Category Codes |
6T; 57Y; 68E; 68G |
| NTIS Prices |
(Order as PB-279 272, MF A01) |
| Primary Description |
500/01 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
323738103 |
| Origin |
NTIS |
| Type |
CAT |
