| Main Title |
Permeation of Mouse Skin and Silicone Rubber Membranes by Phenols: Relationship to In vitro Partitioning (Journal Version). |
| Author |
Jetzer, W. E. ;
Huq, A. S. ;
Ho, N. F. H. ;
Flynn, G. L. ;
Duraiswamy, N. ;
|
| CORP Author |
Michigan Univ., Ann Arbor. Coll. of Pharmacy.;Health Effects Research Lab., Research Triangle Park, NC. |
| Publisher |
c1986 |
| Year Published |
1986 |
| Report Number |
EPA-R-809229; EPA/600/J-86/476; |
| Stock Number |
PB89-106876 |
| Additional Subjects |
Phenols ;
Membranes ;
Skin ;
Silicone resins ;
Permeability ;
Separation ;
Elastomers ;
Diffusion ;
Solubility ;
Organic solvents ;
Water ;
Nitrophenols ;
Toxicology ;
Reprints ;
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB89-106876 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
7p |
| Abstract |
A discrepancy has been noted in the relationship between the relative skin permeabilities of phenols and their lipophilicities as expressed in commonly used octanol/water partition coefficients. The permeability coefficients of 4-nitrophenol and several other phenols through skin and a model lipophilic membrane made of silicone rubber were found to be independent of concentration, ruling out concentration dependent molecular aggregation as the cause of the partitioning-permeability incongruity. An unexpectedly low permation rate was observed for the diffusion of 4-nitrophenol through the synthetic, silicone rubber membrane, confirming the phenol's anomalous position in permeability relative to the octanol/water partitioning scale. However, when o/w partition coefficients for the phenolic compounds based on either n-hexane, methylene chloride, chloroform or silicone rubber as the water immiscible phase are used, permeability coefficients for the skin and the synthetic membrane followed expected permeation-partitioning dependencies. |
| Supplementary Notes |
Pub. in Jnl. of Pharmaceutical Sciences, v75 n11 p1098-1103 Nov 86. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Permeation of Mouse Skin and Silicone Rubber Membranes by Phenols: Relationship to In vitro Partitioning (Journal Version). |
| Category Codes |
99F; 57Y |
| NTIS Prices |
Not available NTIS |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
833027879 |
| Origin |
NTIS |
| Type |
CAT |
