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Main Title Simple Flow-Limited Model for Exchange of Organic Chemicals at Fish Gills.
Author Erickson, R. J. ; McKim, J. M. ;
CORP Author Environmental Research Lab.-Duluth, MN.
Publisher c1990
Year Published 1990
Report Number EPA/600/J-90/318;
Stock Number PB91-146720
Additional Subjects Pharmacokinetics ; Toxic substances ; Gills ; Trout ; Mathematical models ; Biological transport ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB91-146720 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 9p
Abstract A mathematical model for the exchange of organic chemicals by fish gills was formulated based solely on the limitations imposed by the flows of water and blood into the gills. For large rainbow trout, the model was found to closely follow the magnitude and trends of observed gill uptake rates over a range of octanol/water partition coefficient from 1 to ten to the sixth power. Observations averaged only about 30% less than model predictions. The modest lack-of-fit is presumably due to the effects of diffusional barriers and ionization which would further limit uptake, although uncertainties in model parameters and data are likely also partly responsible. The analysis suggests that these basic physiologicalparameters are of major importance in the regulation of exchange at fish gills and should be accounted for in more detailed toxicokinetic models. Also, the simple model could by itself be useful for approximate assessments of accumulation of organic chemicals by fish.
Supplementary Notes Pub. in Environmental Toxicology and Chemistry, v9 p159-165 1990. Presented at the Symposium on Toxicokinetics, Annual Meeting of the Society of Environmental Toxicology and Chemistry (8th), Pensacola, FL., November 9-12, 1987.
NTIS Title Notes Journal article.
Title Annotations Reprint: Simple Flow-Limited Model for Exchange of Organic Chemicals at Fish Gills.
Category Codes 57Y; 68D
NTIS Prices PC A02/MF A01
Primary Description 600/03
Document Type NT
Cataloging Source NTIS/MT
Control Number 110224793
Origin NTIS
Type CAT