|Simple Flow-Limited Model for Exchange of Organic Chemicals at Fish Gills.
Erickson, R. J. ;
McKim, J. M. ;
|Environmental Research Lab.-Duluth, MN.
Toxic substances ;
Mathematical models ;
Biological transport ;
|Some EPA libraries have a fiche copy filed under the call number shown.
|A mathematical model for the exchange of organic chemicals by fish gills was formulated based solely on the limitations imposed by the flows of water and blood into the gills. For large rainbow trout, the model was found to closely follow the magnitude and trends of observed gill uptake rates over a range of octanol/water partition coefficient from 1 to ten to the sixth power. Observations averaged only about 30% less than model predictions. The modest lack-of-fit is presumably due to the effects of diffusional barriers and ionization which would further limit uptake, although uncertainties in model parameters and data are likely also partly responsible. The analysis suggests that these basic physiologicalparameters are of major importance in the regulation of exchange at fish gills and should be accounted for in more detailed toxicokinetic models. Also, the simple model could by itself be useful for approximate assessments of accumulation of organic chemicals by fish.
|Pub. in Environmental Toxicology and Chemistry, v9 p159-165 1990. Presented at the Symposium on Toxicokinetics, Annual Meeting of the Society of Environmental Toxicology and Chemistry (8th), Pensacola, FL., November 9-12, 1987.
|NTIS Title Notes
|Reprint: Simple Flow-Limited Model for Exchange of Organic Chemicals at Fish Gills.
|PC A02/MF A01