||Environmental Impacts on the Physiological Mechanisms Controlling Xenobiotic Transfer Across Fish Gills.
McKim, J. M. ;
Erickson, R. J. ;
||Environmental Research Lab.-Duluth, MN.
Water pollution effects(Animals) ;
Biological transport ;
Organic chemicals ;
Mathematical models ;
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||Fish physiologists have provided the basic information on gill morphology, gill function, and vascular dynamics with which to understand branchial flux of gases, water, and ions. In addition, pharmacologists and toxicologists, working in the area of drug action, have characterized the physicochemical attributes of xenobiotic chemicals that determine their rate of movement across biological membranes. Recently, aquatic toxicologists have applied the information to the question of what mechanisms control the movement of organic chemicals across fish gills and how exchange is affected by chemical properties. Mathematical models were developed that predict gill exchange as a function of basic processes such as water flow across the gills, blood flow through the gills, partitioning of the chemical between water and blood, and diffusion between blood and water across gill epithelia. Such mechanistic models can predict the effects of environmental conditions on exchange rates of xenobiotics. To fully develop a predictive capability for xenobiotic uptake and distribution by fish, it will be necessary to incorporate these gill models into emerging, physiologically based models for the entire animal.
||Pub. in Physiological Zoology, v64 n1 p39-67 Feb 91.
|NTIS Title Notes
||Reprint: Environmental Impacts on the Physiological Mechanisms Controlling Xenobiotic Transfer Across Fish Gills.
||68A; 57Y; 57H
||PC A03/MF A01