| Main Title |
Cytotoxity to Alveolar Macrophages of Metal Oxides Adsorbed on Fly Ash. |
| Author |
Aranyi, Catherine ;
Andres, Sandra ;
Ehrlich, Richard ;
Fenters, James D. ;
Gardner., Donald E. ;
|
| CORP Author |
IIT Research Inst., Chicago, Ill.;Health Effects Research Lab., Research Triangle Park, N.C. |
| Year Published |
1977 |
| Report Number |
EPA-68-02-0761; EPA/600/J-77/112; |
| Stock Number |
PB-278 591 |
| Additional Subjects |
Fly ash ;
Phagocytes ;
Lung ;
Toxicity ;
Metals ;
Immunity ;
Oxides ;
Immunology ;
Toxicology ;
Air pollution ;
Particle size ;
Concentration(Composition) ;
In vitro analysis ;
Cells(Biology) ;
Reprints ;
Macrophages ;
Air pollution effects(Animals) ;
Cytotoxicity
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB-278 591 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
10p |
| Abstract |
Fly-ash particles fractionated into three size ranges (<2, 2 to 5, and 5 to 8 micrometers) and coated with various metal oxides were used to determine whether particle size and surface area are contributing factors to the in vitro toxicity of trace metals for alveolar macrophages (AM). Within a given particle type and exposure concentration, decrease in particle size resulted in decreased viability and increased phagocytosis. The toxic effect was not due to the solubilization of the test elements into the incubating medium. The percentage of lead, nickel, or manganese adsorbed on the fly-ash particles varied within a relatively narrow range and was not affected by the particle size. Since the AM were exposed to the particles on a weight-dose per cell basis, their effective exposure load to the test elements was constant irrespective of the particle size. Thus the greater toxicity of the small particles appears to be due to surface interaction between particles and AM, and toxic effect is surface-area as well as dose related. |
| Supplementary Notes |
Pub. in Pulmonary Macrophage and Epithelial Cells, ERDA Symposium Series 43, p58-65 1977. |
| Title Annotations |
Reprint: Cytotoxity to Alveolar Macrophages of Metal Oxides Adsorbed on Fly Ash. |
| PUB Date Free Form |
1977 |
| Category Codes |
6T; 6E; 6F; 57Y; 57J; 57H; 68G; 68A |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
323736953 |
| Origin |
NTIS |
| Type |
CAT |
