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OLS Field Name OLS Field Data
Main Title Acute Exposures to p-Xylene and Toluene Alter Visual Information Processing (Journal Version).
Author Dyer, R. S. ; Bercegeay, M. S. ; Mayo, L. M. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Publisher 1988
Year Published 1988
Report Number EPA/600/J-88/064;
Stock Number PB89-110365
Additional Subjects Toxicity ; Toluene ; Xylenes ; Amphetamines ; Exposure ; Respiration ; Aromatic hydrocarbons ; Laboratory animals ; Arousal ; Reprints ; Visual cortex ; Oral administration ; Visual evoked potentials
Library Call Number Additional Info Location Last
NTIS  PB89-110365 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 03/14/1989
Collation 10p
Abstract Long-Evans hooded rats were exposed to single doses of toluene (p.o.) at 0, 250, 500 and 1000 mg/kg, to p-xylene (p.o.) at 0, 125, 250, 500, 1000 and 2000 mg/kg, and to inhalation of p-xylene for 4 hrs at 0, 800 or 1600 ppm. The functional integrity of the visual system was evaluated using flash-evoked potentials (FEPs). The data indicated a significant depression in amplitude of FEP peak N3 at 250 mg/kg and higher dosages of toluene and p-xylene. A similar depression in peak N3 amplitude was observed following inhalation exposure to 1600 ppm p-xylene. The effects produced by oral administration of 500 mg/kg p-xylene or toluene lasted at least 8 hr, while the effect of inhaled p-xylene dissipated within 75 min of removal from the exposure. FEP peak N3 is presumed to be related to arousal, such that increase in arousal from a relaxed state should decrease amplitude. Rats administered amphetamine in dosages of .6, 1.2 and 2.5 mg/kg (known to increase arousal) also had reduced N3 amplitude. The effects of p-xylene and toluene on FEPs, while indicative of altered processing of visual information, may be secondary to changes in arousal or excitability.
Supplementary Notes Pub. in Neurotoxicology and Teratology, v10 p147-153 1988.
NTIS Title Notes Journal article.
Title Annotations Reprint: Acute Exposures to p-Xylene and Toluene Alter Visual Information Processing (Journal Version).
Category Codes 57Y; 57I; 57U; 44G; 68G
NTIS Prices PC A02/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 834424849
Origin NTIS
Type CAT